1. ()
O CH2 OH
|| /
N CH3 - O C CH H2SO4 + lO4 →
\ 2
C6H5
.
O CH2OH O CH2OH
|| / || /
→ H N+ CH3 - O C CH ClO4- + HN+CH3 -OCCH HSO4-
\ \
C 6 H 5 C 6 H 5
f. = M1/z =
2. , ()
:
[Atr]2 H2SO4 + 2 NOH → 2 Atr + N2SO4 + 2 H2O
f. = M1/z =
:
NB!
.
, : :
6 7
1 5 NH
N
8
2 4
N N
3 9
(2,6-), () (1) - () (2)
͠
NH NH
N HN
|
|
|
↔
Π O
N N NH N
(1) (2)
, , , , ( , ) .
Cofftinum
Caffeine *
N CH 3
H 3 C N
2
O
N N
|
CH 3
1,3,7-
1.
2.
3.
Cof. HI I4 ↓
4.
5.
1. ( 11)
N CH3
H3C N (CH3CO)2O
+ HClO4 
O
N N
|
CH3 .
N CH3
H3C N
→ ClO4-
O
N N+ - H
|
CH3
f. = M1/z =
2. , ( )
:
N CH3
H3C N
+ 2 I2 + HI → Cof. HI I4 ↓
O
N N
|
CH3 = .
I2 + 2 Na2S2O3 → 2 NaI + Na2S4O6
f. = M1/z =
:
-
Coffeinum-natrii benzoas
Caffein-benzoate Sodium*
N CH3
H3C N COONa
O
N N
|
CH 3
)
)
|
|
|
) -
)
3.
4.
( 38-40%)
, ᠠ
(. )
:
Cof. + 2 I2 + HI → Cof. HI I4 ↓
= .
I2 + 2 Na2S2O3 → 2 NaI + Na2S4O6
f. = M1/z =
( 58-62%)
, ,
:
.
f. = M1/z =
-
, - , , ,
: 1,0
- 0,5
200
(. ),
𠠠
- 100%
T. -------------------
ω%-
, %
100%
. / Na = ------------------
%
- 5%
:
| Theobrominum Theobromine* | Theophyllinum Theophylline* |
|
N CH3
HN
O
N N
|
CH3
| 
NH
H 3 C N
2Π
O
N N
|
CH3
|
| 3,7- | 1,3- |
OH
N CH3 N CH3
HN N NaOH
↔ →
O O
N N N N
| |
CH3 CH3
Na O-
N CH3 N CH3
N CoCl2 N
→ → Co ↓
O O
N N N N
| | 2
CH3 CH3
O
NH N - Na
H3C - N NaOH H3C - N
→ →
O O
N N N N
| |
CH3 CH3
O
N-
CoCl2 H3C - N
→ Co ↓
O
N N
| 2
CH3
OH
HN N CH3 N N CH3
↔ NaOH
O O Π +AgNO3 → NaNO3 +
N N N N
| |
CH3 CH3
Ag
N N CH3
+
O ↓
N N
|
CH3
O
H3C - N NH H3C - N N-Ag
NaOH
O + AgNO3 → O ↓ + NaNO3
N N N N
| |
CH3 CH3
