Ê ïðîèçâîäíûì èìèäàçîëà îòíîñÿòñÿ òàêèå ËÑ, êàê ïèëîêàðïèíà ãèäðîõëîðèä, äèáàçîë, êëîôåëèí, ìåòðîíèäàçîë, êëîôåëèí è äð.
Ïèëîêàðïèíà ãèäðîõëîðèä
Pilocarpini hydrochloridum
Pilocarpine hydrochloride *
* *
Ñ2 H 5 CH 2 N – CH 3
• ÍÑ1
|
ëàêòîííîå êîëüöî èìèäàçîëîâûé öèêë
Ñâîéñòâà
Ïîäëèííîñòü
1.
2.
3.
4.
R3N • HCl + AgNO3 → AgCl ↓ + R3N • HNO3
5.
6.
Ñ 2 H5 CH2 N – CH3 N≡N
NaOH
+ Cl →
SO3Na
Ñ 2 H5 CH2 N – CH3
®
N=N SO3Na
7.
8.
Êîëè÷åñòâåííîå îïðåäåëåíèå
Ïî ÃÔ
Ìåòîä
Ñ 2 H5 CH2 N – CH3 CH3 – C = O
• ÍÑ 1 \
+ HClO4 O →
/
CH3 – C = O
ìîëü ýêâ.
Ñ 2 H5 CH2 N – CH3
Ñ 1O4 + CH3 – C = O + CH3 ÑÎÎÍ
|
|
|
|
fýêâ. = M1/z =
Ýêñïðåññ - àíàëèç
1. Ìåòîä , âàðèàíò
Ìåòîä îñíîâàí íà
Ìåòîäèêà:
R3N • HCl + NaOH → NaCl + R3N + H2O
ìîëü ýêâ.
fýêâ. = M1/z =
2. Ìåòîä
Ìåòîä îñíîâàí íà
Ìåòîäèêà:
R3N • HCl + AgNO3 → AgCl↓ + R3N •HNO3
ìîëü ýêâ.
fýêâ. = M1/z =
Ïðèìåíåíèå
Õðàíåíèå
Äèáàçîë
Dibazolum
Bendazole Hydrochloride *
N
CH2 • HCl
N
|
H
2-áåíçèëáåíçèìèäàçîëà ãèäðîõëîðèä
Ñâîéñòâà
Ïîäëèííîñòü
1.
2.
3.
N HCl N
CH2–C6H5+ I2 +KI → CH2-C6H5 • I2• HI↓
N N
| |
H H
4.
R3N • HCl + NÍ4OH → NÍ4Cl + R3N↓ + H2O
NÍ4Cl + AgNO3 → AgCl↓ + NÍ4NO3
5.
Êîëè÷åñòâåííîå îïðåäåëåíèå
Ïî ÃÔ
Ìåòîä
CH3 – C = O
N \
CH2 – C6H5 • HCl + HClO4 + O →
/
N – H CH3 – C = O
ìîëü ýêâ.
+
N – H
→ CH2–C6H5 ClO4- + CH3 – C = O + CH3 – C = O
| |
N – H Cl OH
fýêâ. = M1/z =
Ýêñïðåññ-àíàëèç
1. Ìåòîä , âàðèàíò
Ìåòîä îñíîâàí íà
Ìåòîäèêà:
R3N • HCl + NaOH → NaCl + R3N + H2O
ìîëü ýêâ.
fýêâ. = M1/z =
2. Ìåòîä
Ìåòîä îñíîâàí íà
Ìåòîäèêà:
R3N • HCl + AgNO3 → AgCl↓ + R3N •HNO3
ìîëü ýêâ.
fýêâ. = M1/z =
Ïðèìåíåíèå
Õðàíåíèå
Ëåêàðñòâåííûå ñðåäñòâà, ïðîèçâîäíûå ïèðèäèíà è ïèïåðèäèíà.
Êëàññèôèêàöèÿ ëåêàðñòâåííûõ ïðåïàðàòîâ.
Ïðîèçâîäíûå íèêîòèíîâîé êèñëîòû
(ïèðèäèí-3-êàðáîíîâîé êèñëîòû)
· íèêîòèíîâàÿ êèñëîòà
· íèêîòèíàìèä
· äèýòèëàìèä íèêîòèíîâîé êèñëîòû
· è ò.ä.
2. Ïðîèçâîäíûå èçîíèêîòèíîâîé êèñëîòû
|
· èçîíèàçèä
· ôòèâàçèä
3. Ïðîèçâîäíûå ïèðèäèíìåòàíîëà
· îêñèìåòèëïèðèäèíîâûå âèòàìèíû
· ïèðèäîêñèíà ãèäðîõëîðèä
Íèêîòèíîâàÿ êèñëîòà
Acidum nicotinicum
Nicotinic Acid *
COOH
N
(Âèòàìèí ÐÐ)
ïèðèäèí-3-êàðáîíîâàÿ êèñëîòà
Ñâîéñòâà
Ïîäëèííîñòü
1.
COOH Na2CO3
→ ↑ + CO 2 ↑
N N
2.
COOH COO-
2 + CuSO4 → Cu2+↓ + H2SO4
N N 2
3.
COOH COO-
2 + CuSO4 + NH4SCN → Cu(SCN)2 + (NH4)2SO4
N N 2
4.
Êîëè÷åñòâåííîå îïðåäåëåíèå
1. Ìåòîä , ñïîñîá
Ìåòîä îñíîâàí íà
Ìåòîäèêà:
COOH COONa
+ NaOH → + H2O
N N
ìîëü ýêâ
fýêâ = M1/z=
Ïðèìåíåíèå
Ôîðìà âûïóñêà:
Ïîáî÷íîå äåéñòâèå:
Õðàíåíèå
Ñïèñîê
Îêñèìåòèëïèðèäèíîâûå âèòàìèíû
Ïèðîäîêñèíà ãèäðîõëîðèä
Pyridoxini hydrochloridum
Vitaminum B6
Pirodoxine Hydrochloride*
CH2 – OH
|
HO – – CH2 – OH
• HCl
/
H3C N
2-ìåòèë-3-îêñè-4,5- äè-(îêñèìåòèë)-ïèðèäèíà ãèäðîõëîðèä
Ñâîéñòâà
.
Ïîäëèííîñòü
1.
2.
3.
4.
5.
CH2OH CH2OH
| Cl |
HO – – CH2OH HO – – CH2OH
+ Ñ l – N = =O → + HCl
/ / \
H3C N Cl H3C N N = =O
6. (BiI3 â KI) -
7. (SiO2•12WO3•2H20 - ðåàêòèâ Áåðòðàíà) -
8. (H3PO4•12WO3•2H2O - ðåàêòèâ Øåéáëåðà) –
9.
R3N • HCI + AgNO3 → AgCI ↓ + R3N • HNO3
Êîëè÷åñòâåííîå îïðåäåëåíèå
1. Ìåòîä (ÃÔ)
CH2OH CH2OH
| CH3 – C = O |
HO – – CH2OH \ HO – – CH2OH
• HCl + HClO4 + O → ClO4-+ CH3 – C = O + CH3 – C = O
/ / / + | |
H3C N CH3 – C = O H3C N Cl OH
ìîëü ýêâ. |
H
fýêâ = M1/z=
Ýêñïðåññ-àíàëèç
1. Ìåòîä , âàðèàíò
Ìåòîä îñíîâàí íà
Ìåòîäèêà:
R3N • HCl + NaOH → NaCl + R3N + H2O
1 ìîëü 1 ýêâ.
fýêâ. = 1 M1/z = Mm
2. Ìåòîä
Ìåòîä îñíîâàí íà
Ìåòîäèêà:
R3N • HCl + AgNO3 → AgCl↓ + R3N •HNO3
ìîëü ýêâ.
fýêâ. = M1/z =
Ïðèìåíåíèå
Ôîðìà âûïóñêà:
Õðàíåíèå