b- , . , .
.
. . . Û Û Û .
. . .
- , . . , , . : a b. 16 a‑ 8 b‑. , . . . : b2‑ ; ; , ( , b4‑ ).
. a- b2 :
b2/a-L, CD18/CD11A, LFA1, Leu CAM;
b2/a-M, CD18/CD11B, CR3, CAMb, Mac1, Mo1, OKM-1;
b2/a-X, CD18/CD11C, p150, p150,95, Leu CAMc.
IIb - IIIa . , . , , , , IIb-IIIa . IIb-IIIa , .
MAC1 (120980, . a-M; ITGAM, a- 3, CD11B.
VLA4 (192975, . a-4; ITGA4, 4, VLA4, CD49D.
VLA5 (135620, . a-5; ITGA5, a- , Very Late Activation protein 5 5, VLA5A.
( ) , (.) . .
1 ‑ ‑. , ; 1 , ‑., , , . 1 ; 1: , , , . 1: T‑., ‑., , , , . 1: 1a ( , pI5) 1b ( , pI7). 1. : , ., A.
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2 , ‑. (CD4>CD8), ‑, ‑. (‑, T‑.), ‑. NK‑. 2 , a, b g (D25,; a‑ g‑ [ ] . Û ‑. .
3 ‑. . 3 ‑ , ‑ (CFU‑GEMM), ‑ , , , , . 3 , a‑, b‑ (b‑ 5 GM‑CSF) g‑.
4 ‑. ( T‑. ) , T4‑., . , . Û ‑. 1 Û . .
5 ( ) ; 5 ‑., 5 ‑ ( ‑ T‑.); 3 GM‑CSF (, 5) ‑.
6 , , Ig ‑.; 6, MyD118, . 6 , ( ), , . : ‑. 2 Û ‑b2 Û .
7 , ‑ ‑., ‑. 7 g‑ 7, 2, 4, 7, 9, 15.
8 ‑. (), , , ; . : Û Û Û Û .
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9 ( ‑./ ) , ‑. 9 ( ), 9 .
10 g‑ ‑. , /, ‑ ‑. 10 ‑ ‑ . 10 .
11 ( , , ) , , ‑ ‑.
12 ( NK‑ NKSF) g‑ ‑. NK‑ , ‑ ‑. 2 : 12 (p35, .) 12 (p40, . 2). 12 .
13 ‑ , ; 13 ‑., IgG4 IgE . 13 4 : ‑. CD23, IgM, MHC II; 13 4. , 4 13 4 ; , 13 .
14 ‑. , ‑. Ig.
15 ‑. , ‑. NK‑.
16 ( . LCF) , CD4+ ., .
17 ( ‑. 8) 6 8 ICAM1, E2. 17 .
18 (g‑H‑ ) 1b. , ‑. 2 GM‑CSF, NK‑, FAS‑ (CD95) ‑. NK‑, g‑ NK‑, ‑ ‑.; GM‑CSF .
21 2 15, ‑ B‑., NK‑.
, , , , .
() , ; , , 4 (a, b, g, w).
a ‑ ( ) B‑, T‑, NK‑ ; : T‑ ‑, NK‑.
b ‑ ( , b1; b2, 6; b3) , a‑; : T‑ (b2, . 6).
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b 2 ‑ , .6.
g ‑ ( ) NK‑ T‑ , ; MHC I II, , Ig , , .
( ). - () , , , ().
, .
, Ca2+ ( , ).
, , , .
Ca2+- ; Ca2+ (, ); .
Ca2+‑ . . 50 Ca2+.
. ("") . . . "" , (), . .: ‑ (, ), . . , , , , .
, 32 , . 3421 ( ). . 2+‑ . , . , . CALC1 (114130, 11p15.2-p15.1) ., (21 ) a. CALC2 (114160, 11pter-11q12) , . ( ) b. . . CALC2 CALC3 ‑ , - . CALC2 CALC3 ‑ . . 2+ , / . . : . 2+ ( 2+); . ( ); . 2+, Na+ ( ); . . . , . ‑ (, ) . a b (37 ) ( ). , , . , , .
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, 1a,25‑ D3, 1a,25‑, 9,10‑‑5,7,10(19)‑‑1a,3b,25, 1,25()2D3, D3 . , . D3 , ; D .
.
., . .
. (K+‑.) , ; : , , . K+‑. ( Ca2+ ) K+‑. K+‑. . G ‑ ‑ K+ ‑ . G‑ + .
. (Ca2+‑.) , ( ) . ( ) (, ) Ca2+‑. Ca2+‑. , (a1, a2, b, g, d). a1 (4 ) b (2 ) Ca2+‑. . , Ca2+‑. , , , a1‑. Ca2+‑. Ca2+‑. L ( long lasting, ), T ( transient, ), N ( neuronal, ), P ( P urkinje). Ca2+‑. L‑ , ‑ Ca2+‑. .
‑ . 1,4,5‑ 1,4,5‑‑ Ca2+‑. . 1,4,5‑ I (IP3R1) , , 1 , , . IP3R1 , ‑ , .
. (Na+‑.). (, , , ) Na+‑. , . Na+‑. , . Na+‑. ; a‑ Mr 260 b‑ (Mr 33‑38 ). Na+‑. a‑ ( 6 ). a‑ Na+‑. . Na+‑. (Na+‑.) , ‑; Na+‑. 65% Na+‑. .
‑ . , , , . , .
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. (Cl‑‑.) , , , . CLCN1, Cl‑‑., . CLCN5, Cl‑‑. CLC5, , ‑ ‑ . (), 12% 5% , 45% .
() , Candida, C. albicans (., , ).
Cannabis sativa var indica ( Moraceae); ( , ‑ [ , ‑ ]). Û . : , , , , , , .
).
, , ‑, , ; P , (CGRP) ; NMDA, AMPA ; - .
. . . Û .
() . . 25‑50 . , 100 . 200 . , 320‑400 . . . .
; .
, , , , . (1995) (. 04).
¸. 04
¸. 04 , .
04. (.).
. . . . * |
. ( ) . . . . (, , , ) ( , ) . ( ) |
. ( ) |
* . (Â), .
. ( : b‑ , TnT, ). . ( : , ( ).
, : , , .
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, , . Û Û .
( CASP) , , , . . . . (.‑2, -8 -9). . . (.‑3, -6 -7), , (, [-] , 2.4.2.30).
. Alnemri . (1996). 11 . ICE/CED-3 (ICE Interleukin 1b Converting Enzyme [ 1], 3.4.22.36; CED-3 CEll Death gene ced-3 Caenorhabditis elegans). caspase (c cysteine), aspase asp (aspartic acid ). (.1, .2,..., .10, .13).
, . .
, .
, .