, . - 2%.
. , , . .
8.
8.1.
, (), , . - :: , (4S, LIPID, HPS, CARE, WOSCOP), (SPARCL -Stroke Prevention by Aggressive Reduction in Cholesterol Levels), .
(, , MSS), - ().
(), 50- , -, , , -, . , , , . - . ,
, -, ; 150-250 / (4,0-6,5 /) - 1,5-2 (CastelH WR 1992).
- . - 40-60 / (1,0-1,6 /). , - -. (-, , -) , , 2 , .
8.2.
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, - , : ( ), .
Seven Countries Study (Keys A., 1980),
20 3 " ", 2009; 8(6)
( , ), , , . , , , , , , . - 12763 . - , . , -, . , , , - (4,7 /) 7 , , . ( - 5,6 5,9 / ) , , (Ni Hon San study, 1977).
8.3.
MRFIT. 361 662 35-57 , . (5,2 /), . - 20 , , 4,7 /. , PROCAM, . -, -. 6- AMOR1S (2001 .) , - , 175 553 . , , , -. - -, -, , -, : - / - , / A-I -
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, , / -, - / - / - (P. Durrington, A. Sniderman, Fast Facts- Hyperlipidemia, 2005). - , , . . , : , - , (P. Barter, DALM 2007).
- 4- (, MRFIT, Coronary Primary Prevention Trial, Lipid Research Clinic) , - 1 / 2-3% , , -. Helsiki Heart Study - . - . ILLUMINATE ( - , -) - . , , - .
, - , . , -, -, , .
- 17 , 1 / 32% 76% - . 2007 N. Surwar et al - 29 . , . , , , , , () .
MONICA -
3 " ", 2009; 8(6)
, . 21 (35 , - , , (6,0-6,4 /), - - (4,5 /). 5,0-5,7 /, 5,3 /.
MONICA (1985-1995 .) 9835 25-64 . ( > 5,2 /) 57%; - > 3,4 / - 53%, (>1,7 /) 18%; (- < 1,0 /) 16% ( .., 2003). > 5,7 / 1,3 , < 5,2 /.
.. , Global Programme on Evidence for Health Policy, WHO, World health Report, 2002, 7 23%, 12%. , 0X05,0 / 1,5 , , 5,0 /.
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3 (NCEP III, 2001) - - -. , - 1 % 1%.
8.4. -
INTERHEART - 52
, , , , 30 . 9 (, , , , , , , , ), 90% , . / A-I , 3,25 .
- (>1,5 /) / A-I . : -, ? (post-hoc) IDEAL. . -, - . A-I -. - (> 1,8- 2,1 /) 2,5 , A-I (A. Olsson et al., 2007).
8.5.
, , :
1. -, , - ( A-I) .
2. , - - .
3. ( INTERHEART) / A-I.
9.
, - :
Identification and management of familial hypercholesterolemia (FH): Full guideline-draft version,. National Collaboration Centre for Primary Care and Royal Colledge of Gen eral Practitioners: Feb 2008: ( S. Humphries).
250 - , . - , , - . , ( 1:500),
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, .
- ( , 40% -
1:1000000).
, , - -
9.1. , .
-, , - 9.3.
, ,
. -
, - :
13 /. - , 5-10 ,
, , -
-. 30-40 ;
- , -
1,3 15-20 /;
. , , -
;
, : ,
-. ,
- ,
-
. -, , -
, - , ;
(US MedPed Programm, -
the Simon Broom Register Group (UK), - -
Dutch Lipid Clinic Network). ;
5 , , , ,
.