.
.. . . .
**
CH2OH
C=O
OH CH3
CH3 H
H H 11, 21-- 3,20
O
-, . , . .
**
CH2OH
C=O
CH3
CH3 H
H H
O
, ..- . (+, Na+)
**
CH2OH
C=O
O= CH3 OH
CH3 H 17α,21- -4--3,11,20
H H
O
-, . .. .2 . - ., .
** .
CH2OH
C=O
OH CH3 OH
CH3 H
H H 11, 17α,21--4--3,20
O
-, .. , . , ...
** .
CH3
C=O
HO CH3 OH
H
H H
O
., ...
- -.
21 23
CH3 20 24
CH3
, . .
/ .4-. .. -.
** -.
OH
CH3 COOH 3α,7α,12α--5β- -.
CH3
H
HO H OH
:
1) .-.
2) .. .
** -.
OH
CH3 COOH
CH3
H
HO H
... , . 2- :
)
=O C=O
OH + HNHCH2COOH NHCH2COOH
-H2O -.
)
=O C=O
OH + HNHCH22SO3H NHCH2CH2SO3H
-H2O -.
.-- .-, ..
Na+, K+ - .-.- .
. , . .
O O
C-N-CH2-C Na+
H O-
CH3
HO OH
-.
22 24 26
21
CH3 20 23 25
CH3 27
- ..
. .., 17 ( 8 10)
. (), (), ().
** .
-5- -3, β.
. . ., . .
20% . , . . CH3COOH.
CH3
CH3
HO
** 7-.
- -, -, . - .3.
|
|
|
CH3
CH3
HO
CH3
CH2
HO
.3 () .
** .
22 CH3
24 24--5,7,22--3-β
CH3 23
CH3
H H
HO
CH3
CH3 .2()
HO
2 δ- 6 7, - 2 .
CH3 R
8 7
H 6 H
5
CH2
3 1
HO 2
CH3 R
CH2
...2 19 .
HO
