, , , ! - , , , 54.
, , . . Veldee M. V. //New. Engl. J. Med. 1955; 253:483. . : Wilson G. S. The Hazards... p. 46. - : , , , . , , (Lancet May 21, 1955; p. 1071. . : McBeanE. The poisoned...).
53 Ibid.
54 New York Times, June 8, 1955. . : ibid.
, . , , . 1955 . . , , , . 30 1955 . 2027 273 1954 . - 1955 . : 55-15, 1655-326, 276-144, 74-43, 189-134, - 129-38, - 764-469, - 122-22. . - , , 1 1955 ., , , 79, . 190 , 1954 . 132. 12 . , , , : - 295-298, - 22-25, 235-281, 210-22455.
, , , , 1955 . . . , , . 1954 . , 24 , . , . , -
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55 American Capsule News October 15, 1955. . : . The poisoned... , , . , 1962-1964 . ( ) 331 , 278 53 (Wilson G. S. The Hazards... p. 47).
, . , 10-20 , 40-50 . , : . , , , . , : 1955 . . , , , , , , ECHO56, , . , , , 1959 ., 96 10 , 57. , - , 96 , , .
56 1924 1951 .
. 1952 .
,
. ,
, 1959 .
() .
,
, , ,
. 1959 .,
,
.
,
3-5 . ,
. ,
. . Diodati . J. M. Immunization: history, ethics,
law and health. Quebec, 1999, pp. 114-119.
1999-2000 .
230 253, 63 28 (Progress toward
poliomyelitis eradication. Afghanistan, 1999-2000. MMWR March 2, 2001).
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57 M. . ,
. ., 1966, . 376.
, , , . , 19 2000 ., , 58. , 4 , 2000 , , 4 24 . ... . 1995-96 . 286 , 169 ( 12 ). : 1950- ., . , (44% 45,5% ) -, . , , , 59. , , 350 500 . , , () . , ( , - -), , , , . , , -, 60.
, : , - , -
58 Outbreak of poliomyelitis in the Dominican Republic and Haiti, 2000 MMWR December 8
2000.
59 Khalfan S. et al. Epidemics of aseptic meningitis due to enteroviruses following national
immunization days in Bahrain. Ann. Trop. Paediatr. June 1998; 18(2):101-9.
. Chaves S. S. et al. Coxsackie virus A24
infection presenting as acute flaccid paralysis. Lancet 2001; 357:605.
60 Wong M. Poliomyelitis-like syndrome associated with Epstein-Barr virus infection. Pediatr
Neurol. Mar 1999; 20(3):235-7.
, - ? ! .
- ...
SV-40
1959 . (1903-1989), (NIH), , , , 1955 . , , , - - . , . 1959 . - , , 23 . 9 20 , . , . - , , , , . ( -), , . 1960 . - , , , , , - . , , , , . - . 40- , -, SV (simian virus)-40. , , , , SV-40. 1961 . , ,
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SV-40 . , . , .
, . 21 1961 . - , - . , , . 1962 . . - , , , , 1955 ., . 3 , SV-40, - , . , , , , SV-40, , SV-40, . , SV-40 61. 1976 . SV-40.
61 SV-40 ( ). , - , , 8-10 1968 . , , ( . . ), , 50-90% ... :... , , , . , , (, 8009, 50, 76, . 25-26). ( . . . , 1999, . 161).
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( ), 1960- . . - , 100 (!) . , , , SV-40. 1976-79 . , , , SV-40 . , , , ( ), 17-19 , . , , , . , . .
1988 . , - - , , - (), ( ) , SV-4062. , , . 1979 . , , SV-40, : . , , SV-40. : 1950- 1960- . , , .
62 Bergsagel D. J. et al. DNA sequences similar to those of simian virus 40 in ependymomas and chorioid plexus tumours of childhood. N. Engl. J. Med. 1992; 326:988-993.
1955 1961 . , , , SV-40. SV-40 ... (, ) , 1956-62 . 10 15 SV-40. , ( )... SV-40 . SV-40 ... 63. . , , , . , , , , ! : .
SV-40 - , , , , , , , . 1950- . , , . , 20% , . 48 28 SV-4064. SV-40 , 65. , SV-40 .
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63 Farwell J. R. et al. Effect of SV40 virus-contaminated polio vaccine on the incidence and type of CNS neoplasms in children: a population-based study. Trans. Am. Neurol. Assoc 1979-104:261-4.
64 Carbone M. et al. Simian virus 40-like DNA sequences in human pleural mesothelioma. Oncogene 1994; 9:1781-1790.
65 Carbone M. et al. SV40-like sequences in human bone tumours. Oncogene 1996; 13:527-535.
, 1955-1963 . , , . . - , (), , 1997 ., , , 1955 . 42 , - . - . , 66. , , . , , , SV-40, 67. SV-40, . , , 1961 . - , SV-40, , -, . , SV-40, . , , , -
66 1950-60- .,
, , 1960 . -
120-
. -
.
1960 .,
. - , ,
, -
,
.
67 , SV-40 30%
. . Shah ., Nathanson N. Human exposure to SV40: review and com
ment. Am. J. Epidemiol. 1976; 103:1-212.
SV-40 19 . , , , , SV-40 - 1962 . , . , , 1998 . , , SV-40. , , , . , , . . , ( ), , SV-40. , ( , ), , , ; , SV-40 ( ! )68. , 2003 . . , SV-40 , , . , SV-40 .
68 , . 25 1961 . , , (discarding) , , , , . , . , , , , SV-40. .
2001 . SV-40, 60 . , SV-40 . , ... SV-40. , , . - , , , , - , ... ?
2004 . () . 1960- ., SV-40 . SV-40 , , , 95%. , , , ( 100 ), . - , . . . (1909-1993), (. ), (FDA), , SV-40. ... , . , , ...69.
, SV-40 . , . SV-40 270. , . ,
59 Bookchin D. Vaccine scandal reveals cancer fears. New Scientist July 10, 2004.
70 Gazdar A. F. et al. SV40 and Human Tumours: Myth, Association or Causality? Nat. Rev.
Cancer 2002;957-64
, , . , , , SV-40, . , , , . . , , 71.
, -, (). , () , 1990- . , (-1) , . , , , 72. , ( , , , , .); , . 1991 . - , 1950- . , . 73. 1994 . . , , -