.. , . , .
: 2--3,4,6----2--α-D-, (C9H7N), (K2CO3), (CHCl3) (CH3CN), -2- (CH3-CH(OH)-CH3), (CH3-C(O)-CH3), - (155) [15-17].
:
1) , . ,
2) , .
3) , , .
4) , .
5) , , , . , , .
6) .
7) .
8) .
9) :
, .
, .
, , .
.
.
:
1) , .
2) .
3) .
4) , .
5) , , .
:
1) , .
2) , .
3) , .
|
|
4) , , , . .
. .
, , , , , , , . ( 3 ) , , , , , , .
, . , N-. , , .
, . .
: .
, , . . .
. , , , , . , .
. , .
, : 0,250,5 / 40- .
: . .
, . .
, , . ; . 2 .
, . ; , . .
, . , , , , .
|
|
: .
.
5.6. - [33]
-, 300 / .
5
,
-2- | |||
, /3 | |||
, LD50, / | |||
- /3 | 500-5103 | 500-5103 |
: , -5. .
:
1. . , .. , .
2. . . .
3. , , , . 0,5-2 . , .
6
50 | I 1,0 | . | |
- | 5,0 | ||
50 | II 1,0-15 | . . | |
50 | 50 | ||
50 | III 80-100 | . 1-2 . | |
- | 20-25 | . |
70-75 % , . 0,005 . , 220 , .
. , . . , .
, 23 CH3CN - b-D- [19-22]. , 1,2-- 2--2--D- , .
105, 107, 109, 111 α-D- 104 23 CH3CN 155 . 2-3 . - , 4,5- ( 104) 20 % -. , . 106, 108, 110, 112 49-66%.
|
|
111, , - - . , α-D- 104 - 112, 42%. , . , 112 -.
, 105, 107, 109, 111 - .
1. Phase-transfer catalyzed synthesis of acetylated aryl β-D-glucopyranosides and aryl β-D-galactopyranosides / D. Dess, H. Kleine, D. Weinderg [et al.] // Synthesis. 1981. 11. P. 883-885.
2. Roy R., Stereospecific synthesis of aril β-D- N -acetylglucopyranosides by phase-transfer catalysis / Roy R., Tropper F. // Synth. Commun. 1990. Vol. 20, 14. P. 2097-2102.
3. Lewis P.T., Regiospecific 4- O -b-glucosidation of isoflavones / Lewis P.T., Wähälä K.// Tetrahedron Lett. 1998. Vol. 39. P. 9559-9562.
4. .. - . : , 1994. 345 .
5. Jensen K.J. O -Glycosylations under neutral or basic conditions // K. J. Jensen Chem. Soc., Perkin Trans. 2002. 1. P. 2219-2233
6. 1,2- - / . ., .. , .. , [ .] // . . 1986. . 56, 1. . 181-187.
7. .. / .. , .. .: , 1978. 180 .
8. Jensen K.J. O-Glycosylations under neutral or basic conditions / K.J. Jensen // J. Chem. Soc., Perkin Trans. 2002. 1. P. 2219-2233
9. Konishi F. Synthesis and taste of some flavones and dihydrochalcone glycosides in which carbohydrate moieties are located at differing positions of the aglycones / Konishi F., Esaki S., Kamiya Sh. // Agric. Biol. Chem. 1983. Vol. 47, 7. P. 1419-1429.
10. Tanaka M. The rates of hydrolysis of some substituted phenyl 2-acetamido-2-deoxy-α- and β-D-glucopyranozides / Tanaka M., Kyosaka S., Ito Y. // Chem. Pharm. Buii. 1973. Vol. 21, 9. P. 1971-1977