Alexander V. Ivanov
Golubinskaya str., 29-3-953
Moscow, 117463, Russia
Tel: 7(495)422-1554
7(925)068-3630
E-mail: [email protected]
Engelhardt Institute of Molecular Biology
Russian Academy of Sciences
Vavilov str., 32
Moscow, 119991, Russia
Tel: 7(499)-135-6065
Fax: 7(499)-135-1405
| Personal Information | |
| Date and Place of Birth | Jan 13, 1982, Moscow, Russia |
| Citizenship | Russia |
| Marital status | Married, three children |
| Languages | English (advanced), Russian (native) |
| Objective | |
| Professional Experience and Education | |
| 2016 - present 2009 - 2016 2008 - 2009 2007 - 2008 | Leading research associate Engelhardt Institute of Molecular Biology, Russia Senior researcher Engelhardt Institute of Molecular Biology, Russia Researcher Engelhardt Institute of Molecular Biology, Russia Junior researcher Engelhardt Institute of Molecular Biology, Russia |
| Graduate research (student) | |
| 2003- 2006 | Engelhardt Institute of Molecular Biology, Russia |
| Scientific Advisors: Prof. Marina K. Kukhanovaand Prof. Sergey N. Kochetkov | |
| Thesis on: Hepatitis C virus RNA-dependent RNA polymerase: expression, novel non-nucleoside inhibitors, and protein-protein interaction | |
| 1998-2003 | B.S. and M.S. in Chemistry of Biologically Active Compounds |
| Chemistry Department, Lomonosov Moscow State University, Russia | |
| Scientific Advisors: Maxim V Jasko and PhDAlexey R Khomutov | |
| Diploma thesis on: (Z)- and (E)- isomers of 9-(3-phosphonylmethoxyprop-1-en-1-yl)adenine and their diphosphates: synthesis and biological properties | |
| Visiting Scientist | |
| 2008, February-April | Visiting scientist University of Maryland, Baltimore County (UMBC) (Baltimore, USA) Scientific Advisor: Prof. PhD Katherine L. Seley-Radtke Project on: Studying substrate properties of modified nucleoside triphosphates towards DNA and RNA polymerases |
| 2006, June-August | Visiting scientist |
| Swedish Institute for Infectious Disease Control (Karolinska Institutet, Stockholm, Sweden) | |
| Scientific Advisor: Prof. PhD Helene Norder | |
| Project on: Genotyping of HCV isolates from serum from patients with normal ALT level | |
| Honors and awards | |
| Prize-winner, Moscow Government Award for Students (Natural Sciences) Soros Student, International Soros Science Education program | |
| M.S. diploma with excellence in Chemistry Department, Moscow State University, Russia | |
| Best PhD Student of Russian Academy of Sciences (also scholarship of Russian Science Support Foundation) Medal of Russian Academy of Sciences | |
| Scholarships | |
| 2004-2008 | Scholar of Centre for Medical Studies, University of Oslo, Moscow, Russia |
| Russian Science Support Foundation | |
| Scholarship for attendance of Keystone Symposia Nucleic Acid Enzymes | |
| Memberships | |
| 2003-present | Russian Biochemical Society (Russian branch of FEBS) |
| 2014-present | Society for Free Radical Biology & Medicine (SFRBM) |
| Reviewer in the scientific journals | Biochemistry (Moscow); Molecular Biology (Moscow); Protein Expression Purification; PLoS One; Infection, Genetics and Evolution, Oncotarget, Int.J.Mol.Sci., Int.J Biol.Sci. |
| Teaching Experience | |
| Advisor of O.A. Smirnova (Batyunina) (PhD. thesis: Influence of hepatitis C virus proteins on regulation of oxidative stress and metabolism of biogenic polyamines Advisor of A.O. Kuzyakin (M.S. thesis: Novel non-nucleoside inhibitors of hepatitis C virus RNA-dependent RNA polymerase defended in Chemistry Department, Lomonosov Moscow State University, Russia) | |
| Advisor of A.N. Korovina (M.S. thesis: Optimization of expression of hepatitis C virus RNA-dependent RNA polymerase defended in Chemistry Department, Moscow State University, Russia) | |
| Advisor of V.Yu. Kost (M.S. thesis: Novel N1-alkylated uracil derivatives inhibitors of HIV-1 reverse transcriptase defended in Chemistry Department, Moscow State University, Russia) | |
| Advisor of O.A. Smirnova (Batyunina) (M.S. thesis: Study of influence of hepatitis C virus proteins on cellular system of defense from oxidative stress defended in Department of technology of organic compounds and chemical-pharmaceutical substances, Russian University of Chemistry and technology, Russia) |
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Publications
1. Kuzmenko Yu.V., Smirnova O.A., Ivanov A.V., Starodubova E.S., Karpov V.L. The nonstructural protein 1 of tick-borne encephalitis virus induces oxidative stress and activates antioxidant defense by Nrf2/ARE pathway. Intervirology, in press.
2. Tunitskaya V.L., Eliseeva O.V., Valuev-Elliston V.T., Tyurina D.A., Zakirova N.F., Khomich O.A., Kalis M., Latyshev O.E., Starodubova E.S., Ivanova O.N., Kochetkov S.N., Isaguliants M.G., Ivanov A.V. Prokaryotic Expression, purification and immunogenicity in rabbits of small antigen of hepatitis delta virus. Int. J. Mol. Sci., 2016, 17(10), 1721.
3. Smirnova O.A., Ivanova O.N., Mukhtarov F.Ch., Tunitskaya V.L., Jansons J., Isaguliants M.G., Kochetkov S.N., Ivanov A.V. Analysis of the domains of hepatitis C virus core and NS5A proteins that activate Nrf2/ARE cascade. Acta Naturae, 2016, 8(3), 155-159.
4. Magri A., Ozerov A.A., Tunitskaya V.L., Valuev-Elliston V.T., Wahid A., Pirisi M., Simmonds P., Ivanov A.V., Novikov M.S., Patel A.H. Exploration of acetanilide derivatives of 1-(ω-phenoxyalkyl)uracils as novel inhibitors of Hepatitis C Virus replication, Scientific Reports, 2016, vol. 6, article number 29487.
5. Chudinov M.V., Matveev A.V., Prutkov A.N., Konskantinova I.D., Fateev I.V., Prasolov V.S., Smirnova O.A., Ivanov A.V., Galegov G.A., Deryabin P.G. Novel 5-alkyl(aryl)-substituted ribavirine analogues: synthesis and antiviral activity. Mendeleev Commun., 2016, 26(3), 214-216.
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6. Masalova O.V., Lesnova E.I, Permiakova K.Yu, Samokhvalov E.I., Ivanov A.V., Kochetkov S.N., Kushch A.A. The impact of hepatitis C virus proteins on production of proinflammatory and profibrotic cytokinesin human hepatoma Huh7.5 cells. Molecular Biology (Moscow), 2016, 50(3), (in Russian 486-495).
7. Koloskova O.O., Nikonova A.A., Budanova U.A., Shilovskiy I.P., Kofiadi I.A., Ivanov A.V., Smirnova O.A., Zverev V.V., Sebaykin Yu.L., Andreev S.M., Khaitov M.R. Synthesis and evaluation of novel lipopeptide as a vehicle for efficient gene delivery and gene silencing. Eur. J. Pharm. Biopharm., 2016, 102, 159-167.
8. Smirnova O.A., Ivanova O.N., Bartosch B., Valuev-Elliston V.T., Mukhtarov F., Kochetkov S.N., Ivanov A.V. Hepatitis C virus NS5A protein triggers oxidative stress by inducing NADPH oxidases 1 and 4 and cytochrome P450 2E1. Oxid. Med. Cell. Longev., 2016, vol. 2016, Article ID 8341937. doi:10.1155/2016/8341937.
9. Brault C., Lévy C., Duponchel S., Michelet M., Sallé A., Pécheur E.-I., Plissonnier M.-L., Parent R., Véricel E., Ivanov A.V., Demir M., Steffen H.-M., Odenthal M, Zoulim F., Bartosch B. Glutathione peroxidase 4 is reversibly induced by HCV to control lipid peroxidation and to increase virion infectivity. Gut, 2016, 65(1), 144-154.
10. Ivanov A.V., Smirnova O.A., Petrushanko I.Yu., Ivanova O.N., Karpenko I.L., Alekseeva E., Sominska I., Makarov A.A., Bartosch B., Kochetkov S.N., Isaguliants M.G. HCV core protein uses multiple mechanisms to induce oxidative stress in human hepatoma Huh7 cells. Viruses, 2015, 7(6), 2745-2770.
11. Babkov D.A., Valuev-Elliston V.T., Paramonova M.P., Ozerov A.A., Ivanov A.V., Chizhov A.O., Khandazhinskaya A.L., Kochetkov S.N., Balzarini J., Daelemans B., Pannecouque C., Seley-Radtke K.L., Novikov M.S. Scaffold hopping: Exploration of acetanilide-containing uracil analogues as potential NNRTIs. Bioorg. Med. Chem. 2015; 23, 1069-1081.
12. Orlova O.V., Drutsa V.L., Spirin P.V., Ivanov A.V., Prasolov V.S., Rubtsov P.M., Kochetkov S.N., Beljelarskaya S.N. The role of HCV e2 protein glycosylation in functioning of virus envelope proteins in insect and mammalian cells. Acta Naturae, 2015, 7(1), 87-97.
13. Masalova O.V., Lesnova E.I., Permyakova K.Yu., Ivanova A.V., Tunitskaya V.L., Kushch .. Enhancement of the Immune Response by Codelivery of Hepatitis C Virus Recombinant DNA and Proteins of the Replicative Complex. Molecular Genetics, Microbiology and Virology, 2015, 30(1), 39-47.
14. Isaguliants M., Smirnova O., Ivanov A., Kilpelainen A., Kuzmenko Yu., Petkov S., Latanova A., Krotova O., Engström G., Karpov V., Kochetkov S., Wahren B., Starodubova E. Oxidative stress induced by HIV-1 reverse transcriptase modulates its performance in gene immunization. 2013; Hum Vaccin Immunother. 2013; 9(10), 2111 - 2119.
15. Matyugina E.S., Valuev-Elliston V.T., Babkov D.A., Novikov M.S., Ivanov A.V., Kochetkov S.N., Balzarini J., Seley-Radtke K.L., Khandazhinskaya A.L. 5-Nor carbocyclic nucleosides: unusual nonnucleoside inhibitors of HIV-1 reverse transcriptase. Med. Chem. Comm. 2013; 4, 741-748.
16. Novikov M.S., Valuev-Elliston V.T., Babkov D.A., Paramonova M.P., Ivanov A.V., Gavryushov S.A., Khandazhinskaya A.L., Kochetkov S.N., Pannecouque C., Andrei G., Snoeck R., Balzarini J., Seley-Radtke K.L. N1-substituted 3-benzylpyrimidines as nonnucleoside inhibitors of HIV-1 reverse transcriptase. Bioorg. Med. Chem. 2013; 21(5):1150-1158.
17. Prokofjeva M.M., Valuev-Elliston V.T., Ivanov A.V., Kochetkov S.N., Novikov M.S., Prassolov V.S. Derivatives of Pyrimidines as Effective Non-nucleoside Inhibitors of Wild-Type and Drug-Resistant HIV-1 Reverse Transcriptase. Doklady Biochemistry and Biophysics, 2012, 447, 280281.
18. Timokhova A.V., Bakinovskii L.V., Zinin A.I., Popenko V.I., Ivanov A.V., Rubtsov P.M., Kochetkov S.N., Belzhelarskaya S.N. Effect of deoxynojirimycin derivatives on morphogenesis of hepatitis C virus. Molecular Biology (Moscow). 2012; 46(4), 579-587.
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19. Valuev-Elliston V.T., Ivanov A.V., Orlinson B.S., Gerasimov E.N., Brunilina L.L., Kochetkov S.N., Novakov I.A., Navrotskii M.B. Synthesis and biological activity of new 6-benzylisocytosine derivatives: non-nucleoside HIV-1 reverse transcriptase inhibitors. Pharmaceutical Chemistry Journal, 2012, 46(7), 397-401.
20. Korovina A.N., Tunitskaya V.L., Khomutov M.A., Simonian A.R., Khomutov A.R., Ivanov A.V.*, .. Biogenic polyamines spermine and spermidine stabilize RNA polyamerase and inhibit RNA helicase of hepatitis C virus. Biochemistry (Moscow), 2012, 77(10), 1172-1180.
21. Smirnova O.A., Isaguliants M.G., Hyvonen M.T., Keinanen T.A., Tunitskaya V.L., Vepsalainen J., Alhonen L., Kochetkov S.N., Ivanov A.V. Chemically induced oxidative stress increases polyamine levels by activating the transcription of ornithine decarboxylase and spermidine/spermine-N1-acetyltransferase in human hepatoma HUH7 cells. Biochimie, 2012, 94(9), 1876-1883.
22. Ivanov A.V., Smirnova O.A., Ivanova O.N., Masalova O.V., Kochetkov S.N., Isaguliants M.G. Hepatitis C Virus Proteins Activate NRF2/ARE Pathway by Distinct ROS-Dependent and Independent Mechanisms in HUH7 cells. PLoS One, 2011, 6(9), e24957.
23. Novikov M.S., Ivanova O.N., Ivanov A.V., Ozerov A.A., Valuev-Elliston V.T., Temburnikar K., Gurskaya G.V., Kochetkov S.N., Pannecouque C., Balzarini J., Seley-Radtke K.L. 1-[2-(2-Benzoyl- and 2-benzylphenoxy)ethyl]uracils as potent anti-HIV-1 agents. Bioorg. Med. Chem. 2011; 19(19), 5794-5802.
24. Tunitskaya V.L., Mukovnya A.V., Ivanov A.A., Gromyko A.V., Ivanov A.V., Streltsov S.A., Zhuze A.L., Kochetkov S.N. Inhibition of the helicase activity of the HCV NS3 protein by symmetrical dimeric bis-benzimidazoles. Bioorg. Med. Chem. Letters 2011, 21(18), 5331-5335.
25. Prokofjeva M.M., Spirin P.V., Yanvarev D.V., Ivanov A.V., Novikov M.S., Stepanov O.A., Gottikh M.B., Kochetkov S.N., Fehse B., Stocking C., Prassolov V.S. Screening of Potential HIV-1 Inhibitors/Replication Blockers Using Secure Lentiviral in Vitro System. Acta Naturae. 2011. 3(4), 55-65.
26. Novikov MS, Buckheit RW Jr, Temburnikar K, Khandazhinskaya AL, Ivanov AV, Seley-Radtke KL. 1-Benzyl derivatives of 5-(arylamino)uracils as anti-HIV-1 and anti-EBV agents. Bioorg. Med. Chem. 2010; 18(23), 8310-4.
27. Masalova O.V., Lesnova E.I., Grabovetsky I.I., Smirnova O.A., Ulanova T.I., Burkov A.U., Ivanov A.V., Zaberezhniy A.V., Ataulkhanov A.I., Kusch A.A. DNA immunization by a plasmid encoding a hepatitis C virus nonstructural NS5A protein induces an effective cellular immune response. Molecular Biology (Moscow). 2010; 44(2), 275-83.
28. Karpenko I, Deev S, Kiselev O, Charushin V, Rusinov V, Ulomsky E, Deeva E, Yanvarev D, Ivanov A, Smirnova O, Kochetkov S, Chupakhin O, Kukhanova M. Antiviral properties, metabolism, and pharmacokinetics of a novel azolo-1,2,4-triazine-derived inhibitor of influenza A and B virus replication. Antimicrob Agents Chemother. 2010; 54(5), 2017-22.
29. Masalova OV, Lesnova EI, Pichugin AV, Melnikova TM, Grabovetsky VV, Petrakova NV, Smirnova OA, Ivanov AV, Zaberezhny AD, Ataullakhanov RI, Isaguliants MG, Kushch AA. The successful immune response against hepatitis C nonstructural protein 5A (NS5A) requires heterologous DNA/protein immunization. Vaccine. 2010; 28(8), 1987-96.
30. Starodubova E, Boberg A, Ivanov A, Latyshev O, Petrakova N, Kuzmenko Y, Litvina M, Chernousov A, Kochetkov S, Karpov V, Wahren B, Isaguliants MG. Potent cross-reactive immune response against the wild-type and drug-resistant forms of HIV reverse transcriptase after the chimeric gene immunization. Vaccine. 2010, 28(8), 1975-86.
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31. Matyugina E.S., Alexandrova L.A., Jas'ko M.V., Ivanov A.V., Vasil'ev I.A., Lapteva V.L., Khandazhinskaya A.L., Kukhanova M.K. Structure-functional analysis of interactions of terminal deoxynucleotidyl transferase with new non-nucleoside substrates. Russ. J. Bioorg. Chem., 2009, 35, 376-383.
32. Ivanov A.V., Tunitskaya V.L., Ivanova O.N., Mitkevich V.A., Prassolov V.S., Makarov A.A., Kukhanova M.K., Kochetkov S.N. Hepatitis C virus NS5A protein modulates template selection by the RNA polymerase in in vitro system. FEBS Letts., 2009, 583, 2, 277-280.
33. Ivanov M.A., Ivanov A.V., Krasnitskaya I.A., Smirnova O.A., Karpenko I.L., Belanov E.F., Prassolov V.S., Tunitskaya V.L., Alexandrova L.A. New furano- and pyrrolo[2,3-d]pyrimidine nucleosides and their 5-triphosphates: synthesis and biological properties. Russ. J. Bioorg. Chem., 2008, 34, 5, 661-670.
34. Seley-Radtke K.L., Zhang Z., Wauchope O.R., Zimmermann S.C., Ivanov A., Korba B. Hetero-expanded nucleosides. Design, synthesis and preliminary biological activity. Nucleic Acids Symp. Ser. (Oxf.), 2008, 52, 635-636.
35. Ivanov A.V., Smirnova O.A., Golubeva N.A., Ivanov M.A., Tunitskaya V.L., Shipitsyn A.V., Alexandrova L.A. Base-modified ribonucleosides as potential anti-hepatitis C virus agents. Nucleic Acids Symp. Ser. (Oxf.), 2008, 52, 619-620.
36. Mukovnya A.V., Tunitskaya V.L., Khandazhinskaya A.L., Golubeva N.A., Zakirova N.F., Ivanov A.V., Kukhanova M.K., Kochetkov S.N. Hepatitis C virus helicase/NTPase: an efficient expression system and new inhibitors. Biochemistry (Mosc), 2008, 73, 6, 660-668.
37. Golubeva N.A., Ivanov A.V., Ivanov M.A., Batyunina O.A., Shipitsyn A.V., Tunitskaya V.L., Aleksandrova L.A. New Nucleoside Analogues and Their 5'-Triphosphates: Synthesis and Biological Properties. Moscow University Chemistry Bulletin, 2008, 63, 2, 8993.
38. Korovina A.N., Yasco M.V., Ivanov A.V., Khandazhinskaya A.L., Karamov E.V., Kornilayeva G.V., Kukhanova M.K. New HSV and HIV replication inhibitors on the abse of phosphonate nucleoside analogues. Moscow University Chemistry Bulletin, 2008, 63, 2, 108-111.
39. Jasko M, Khandazhinskaya A, Alexandrova L, Shirokova E, Ivanov A, Kukhanova M. Synthesis of novel alkyl triphosphates and their substrate properties toward terminal deoxynucleotidyltransferase. Nucleosides Nucleotides Nucleic Acids, 2007, 26, 4, 323-34.
40. Kozlov M.V., Polyakov K.M., Ivanov A.V., Filippova S.E., Kuzyakin A.O., Tunitskaya V.L., Kochetkov S.N. Hepatitis C virus RNA-dependent RNA polymerase: study of inhibition mechanism by pyrogallole derivatives Biochemistry (Moscow), 2006, 71, 1253-1259.
41. Ivanov A.V., Korovina A.N., Tunitskaya V.L., Kostyuk D.A., Rechinsky V.O., Kukhanova M.K., Kochetkov S.N. Development of the system ensuring a high-level expression of hepatitis C virus nonstructural NS5B and NS5A proteins. Prot. Exp. Purif., 2006, 48, 1, 14-23.
42. Kukhanova M.K., Zakirova N.F., Ivanov A.V., Alexandrova L.A., Jasco M.V., Khomutov A.R. Hypophosphoric acid is a unique substrate of pyrophosphorolysis catalyzed by HIV-1 reverse transcriptase. Biochem. Biophys. Res. Commun., 2005, 338, 1335-1341.
43. Kukhanova M.K., Ivanov A.V., Jasko M.V. Structure-functional relationship between terminal deoxynucleotidytransferase and 5-triphosphates of nucleoside analogues, Biochemistry (Moscow), 2005, 70, 890-896.
44. Ivanov A.V., Simonyan A.R., Belanov E.F., Alexandrova L.A. Novel 5-modified derivatives of 2'-deoxynucleosides: synthesis and antiviral activity, Russ. J. Bioorg. Chem., 2005, 31, 65-72.
45. Ivanov A.V., Andronova V.L., Galegov G.A., Jasko M.V. Synthesis and antiherpetic activity of (Z)- and (E)- isomers of 9-(3-phosphonylmethoxypropen-1-yl)adenine, Russ. J. Bioorg. Chem., 2005, 31, 1, 58-65.
46. Ivanov A.V., Kozlov M.V, Kuzyakin A.O., Kostyuk D.A., Tunitskaya V.L., Kochetkov S.N. New non-nucleoside inhibitors of hepatitis C virus RNA-dependent RNA polymerase Biochemistry (Moscow), 2004, 69, 7, 782-788.
47. Kochetkov S.N., Andreeva O.I, Ivanov A.V., Kozlov M.V, Mikhailov S.N. Tunitskaya V.L. New blockators of human immunodeficiency and hepatitis C viruses Molecular Medicine (Moscow), 2004, 3, 41-48
48. Shirokova E.A., Jasko M.V., Khandazhinskaya A.L., Ivanov A.V., Yanvarev D.V., Skoblov Y.S., Mitkevich V.A., Bocharov E.V., Pronyaeva T.R., Fedyuk N.V., Kukhanova M.K., Pokrovsky A.G. Uncharged AZT and D4T derivatives of phosphonoformic and phosphonoacetic acids as anti-HIV pronucleosides. J. Med. Chem., 2004, 47, 14, 3606-14.
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49. Shirokova E.A., Jasko M.V., Khandazhinskaya A.L., Ivanov A.V., Yanvarev D.V., Scoblov Yu.S., Pronyaeva T.R., Fedyuk N.V., Pokrovsky A.G., Kukhanova M.K. New phosphonoformic acid derivatives of 3'-azido-3'-deoxythymidine. Russ. J. Bioorg. Chem., 2004, 30, 3, 273-280.
50. Jasko M.V., Ulanova N.Yu., Andronova V.L., Ivanov A.V., Karpenko I.L., Kukhanova M.K., Galegov G.A., Scoblov Yu.S. Synthesis and antiherpetic activity of acyclovir phosphonate esters Russ. J. Bioorg. Chem., 2004, 2004, 30, 6, 539-546.
51. Karpenko I.L., Jasko M.V., Andronova V.L., Ivanov A.V., Kukhanova M.K., Galegov G.A., Skoblov Yu.S. Synthesis and antiherpetic activity of acyclovir phosphonates., Nucleosides, Nucleotides & Nucleic Acids, 2003, 22 (3), 319-329.
52. Zakirova N.F., Ivanov A.V., Scoblov Yu.S., Kukhanova M.K. The influence of pyrophosphate analogs on E. coli inorganic pyrophosphatase activity. Russ. J. Bioorg. Chem., 2002, 28, 6, 497-501.
53. Ivanov A.V., Jasko M.V., Alexandrova L.A. Synthesis of b-H-phosphono-a- phosphonomethyl analogs of nucleoside-5diphospates Russ. J. Bioorg. Chem., 2001, 27, 4, 300-302.
Reviews and chapters
54. Ivanov A.V., Valuev-Elliston V.T., Tyurina D.A., Ivanova O.N., Kochetkov S.N., Bartosch B., Isaguliants M.G. Oxidative Stress, a trigger of hepatitis C and B virus-induced carcinogenesis. Oncotarget. Under minor revision.
55. Ivanov A.V., Valuev-Elliston V.T., Ivanova O.N., Kochetkov S.N., Starodubova E.S., Bartosch B., Isaguliants M.G. Oxidative stress during HIV infection: mechanisms and consequences. Oxid. Med. Cell. Longev., 2016, vol. 2016,Article ID 8910396.
56. Ivanov A.V., Bartosch B., Smirnova O., Isaguliants M.G., Kochetkov S.N. HCV and oxidative stress in the liver. Viruses, 2013, 5, 2, 439-469.
57. Smirnova O.A., Ivanov A.V., Ivanova O.N., Valuev-Elliston V.T., Kochetkov S.N. Cellular systems of defense against oxidative stress and stress of endoplasmic reticulum: mechanisms of regulation and influence of hepatitis C virus. Molecular Biology (Moscow). 2011; 45(1), 127-141.
58. Alexander V Ivanov and Maxim V Jasko. Unsaturated acyclic nucleosides and nucleotides: synthesis and antiviral properties, Chapter in Frontiers in Nucleic Acids, ed. R.F. Schinazi and D.C. Liotta, IHL press, Tucker, GA, 2004, 365-399.
59. Ivanov A.V., Kuzyakin A.O., Kochetkov S.N. Molecular biology of hepatitis C virus, Uspehi biologicheskoy khimii [Advances in Biological Chemistry](Moscow). 2005, 45, 37-86.
