The main clinical utility of either BNP or NT-BNP is that a normal level rules out heart failure. Both markers can also be used for screening and prognosis of heart failure. Both are also typically increased in patients with left ventricular dysfunction, with or without symptoms (BNP accurately reflects current ventricular status, as its half-life is 20 minutes, as opposed to 12 hours for NT-ProBNP).
For patients with congestive heart failure, BNP values will generally be above 100 pg/ml. There is a diagnostic 'gray area', often defined as between 100 and 500 pg/ml, for which the test is considered inconclusive, but levels above 500 pg/ml are generally considered to be positive. This so called gray zone has been addressed in several studies and using clinical history or other available simple tools can help make the diagnosis
C type-natriuretic peptide possesses potent natriuretic, diuretic, and vasodilating activities and are implicated in body fluid homeostasis and blood pressure control. Unlike ANP and BNP, CNP does not have direct natriuretic activity. This is because CNP is a selective agonist for the B-type natriuretic receptorwhereas ANP and BNP are selective for NPRA.
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