.


:

:



,



( , )

:

































 

 

 

 
FAQ

. : 1.0 (3 ) 7-,9- 0.67 (1.7 ) 100 2-6

⇐ 234567891011 ⇒



: 1.0 (3 ) 7-, 9- 0.67 (1.7 ) 100 2-6 , , , .

: 14, 18- 0.5 (5.0 ) 50 0.97 (7,5 ) 6- 0.18 (5.0 ) . 60 6-8. .

3-(4-)-2-- (15). , 0.862 (74%). . =186-188 . 1 (DMSO- d6, δ, .., J, ): 3.76 (, 3, ); 6.86-6.95 (, 2, HAr); 7.26-7.30 (, 2H, HAr); 7.92 8.18 ( . , 2, NH2); 8.29 8.70 ( , 1, J= 14.4, NH ); 10.44 13.70 ( , 1, J= 14.4, NH CH). 1:2. 13 (DMSO- d6, δ, ..) 55.8, 80.4, 85.7, 115.1, 115.4, 116.4, 117.0, 117.1. 117.8, 119.3, 119.5, 120.0, 132.0,133.8, 142.0, 151.6, 152.8, 157.1, 157.5, 177.3, 182.0, 183.1, 190.1, 192.3. -, m/z (I, %): 233 (M+, 63). (%): C, 56.4; H, 5.6; N, 18.4; S, 13.7. C11H11N3OS. (%): C, 56.63; H, 4.75; N, 18.01; S, 13.74.

3- -2 (15). , 0.470 (46%). . =203-205 . -, ν, -1: 2192 (C≡N); 2956, 3014, 3084, 3170 (), 3245, 3402 (NH). 1 (DMSO- d6, δ, .., J, ): 7.08-7.15 (, 1, HAr); 7.30-7.38 (, 4, HAr); 7.94 8.99 ( , 1, NH); 8.04 8.27 ( , 1, NH); 8.41 8.80 ( , 1, J= 14.2, NH ); 10.52 13.75 ( , 1, J= 12.0, NH ). (%): C, 69.9; H, 4.6; N, 20.8; S, 15.6. C10H9N3S. (%): C, 59.09; H, 4.46; N, 20.67; S, 15.78.

3-(4-)-2--2- (15). , 0.831 (70%). . -, ν, -1: 2192 (C≡N); 2964,3091, 3187 (C-H); 3289, 3419 (NH). 1 (DMSO- d6, δ, .., J, ): 7.33- 7.44 (, 4H, HAr); 8.16 8.46 ( , 1, NH2); 8.73 (, 1, J= 13.4, ); 9.00-9.08 ( , 1, NH2); 10.51 13.76 ( , 1, J= 13.2, NH). Z- E- 1:3,5. (%): C, 50.9; H, 3.3; N, 14.8; S, 13.6. C10H8ClN3S. (%): C, 50.53; H, 3.39; N, 14.68; S, 13.49.

3-(4-) -2---2- (15). , 0.868 (70%). . 1 (DMSO- d6, δ, .., J, ): 6.58 7.89, 7.63 8.26 (AA'XX', 4H, J =9.12, HAr);8.57-8.76 (, 2, +NH2); 9.21 9.57 ( , 2, NH2); 10.73 13.86 ( , 1, J= 13.4, NH). Z- E- 1:3. (%): C, 47.9; H, 3.6; N, 22.8; S, 12.7. C10H8N4O2S. (%): C, 48.38; H, 3.25; N, 22.57; S, 12.92.

N --3-(4-)-2- (16). , 0.911 (94%). . .. 158-159 . -, ν, -1: 2191 (C≡N); 3272 (NH). 1 (DMSO- d6, δ, .., J, ): 3.75 3.76 3.77 ( , 3, Me); 4.35 4.84 4.93 ( , 2, J =6.2, 2); 6.81-6.95 (, 2, HAr); 7.38-7.45 (, 7, HAr); 8.12 (, 1, J =14.4, ); 8.24 8.82 ( , 1, J =14.3, ); 7.99 9.26 9.32 ( , 1, NH); 10.45 11.58 13.57 ( , 1, J =14.6, NH). 1:2:3. - (EtOH), λ/ (lgε): 402 (6.78).-, m/z (I, %): 323 (M+, 12). , %: C 66.6; H 5.2; N 13.1; S 10.0. C18H17N3OS. , %: C 66.85; H 5.30; N 12.99; S 9.91.

N --3--2- (16). , 0.659 (75%). . .. 178-179. -, ν, -1: 2203 (C≡N); 2916, 3026 (CH); 3274, 3335 (NH). 1 (DMSO- d6, δ, .., J, ): 4.85 4.94 ( , 2, J= 5.6, 2); 6.91-7.43 (, 10H, HAr); 8.39 (, 1, J =13.6, ), 8.89 (, 1, J =14.0, ); 9.41-9.51 (, 1,N); 10.53 12.50 ( , 1, J =14.0, N). 1:1. - (EtOH), λ/ (lgε): 380 (7.08).-, m/z (I, %): 293 (M+, 13). , %: C 69.4; H 5.4; N 14.1; S 11.1. C17H15N3S. , %: C 69.60; H 5.15; N 14.32; S 10.93.

2-- N --3(4-)- (16). , 0.293 (34%). . =115-118. -, ν, -1: 2192 (C≡N); 3069, 2993, 2933, 2850, 2830 (); 3273, 3130 (NH). 1 (DMSO- d6, δ, .., J, ): 1.19-1.95 (, 10, cyclo -611); 3.78 (, 3, Me); 4.35 (. , 1, ); 6.83-6.92 (, 2, HAr); 7.21-7.30 (, 2H, HAr); 8.37 8.62 ( , 1, J =12.2, N); 8.12 8.23 8.68 ( , 1, J =12.0, ); 10.36 11.61 13.52 ( , 1, J =12.2, N). 1:2:7. (%): C, 65.1; H, 6.3; N, 13.1; S, 10.5. C17H21N3S. (%): C, 64.73; H, 6.71; N, 13.32; S, 10.17.

3-- N --2- (16). , 0.291 (34%). . =129-131. -, ν, -1: 2194 (C≡N); 3072, 2989, 2931, 2835 (); 3270, 3142 (NH). 1 (DMSO- d6, δ, .., J, ): 1.17-1.96 (, 10, cyclo -611); 4.35 (, 1, ); 6.83-7.05 (, 5, HAr); 7.96 8.12 8.64 ( , 1, J =12.6, N); 8.17 8.37 8.69 ( , 1, J =12.0, ); 10.42 11.51 13.27 ( , 1, J =12.4, N). 1:3:4. (%): C, 67.5; H, 6.6; N, 15.0; S, 11.5. C16H19N3S. (%): C, 67.33; H, 6.71; N, 14.72; S, 11.23.

N --2--3-(-1-)-2- (17) . , 0.745 (92%). ... 163-165 . -, ν, (-1): 2186 (C≡N), 2872, 2979, 3026 (CH), 3275 (NH). 1 (DMSO- d6, δ, .., J, ): 1.91-1.94 (, 2, 2); 2.06-2.09 (, 2, 2); 3.73-3.84 (, 2, 22); 4.92 (, 2, J =5.8,2); 7.19-7.26 (, 1H, ArH); 7.25-7.32 (, 4H, ArH); 8.62 (, 1, ); 8.87-8.90 (, 1, NH). (%): C, 66.5; H, 6.1; N, 15.4; S, 11.9. C16H19N3O. (%): C, 66.39; H, 6.31; N, 15.48; S, 11.82.

N --2--3-(-1-)-2- (17). , 0.499 (60%). . .. 208-210 . 1 (DMSO- d6, δ, .., J, ): 1.88-1.93 (, 2, 2); 2.01-2.06 (, 2, 2); 3.70-3.81 (, 4, 22); 4.89 (, 2, J =12.0, 2); 7.16-7.19 (, 1, HAr); 7.22-7.29 (, 4, HAr); 8.59 (, 1, ); 8.84 (, 1,NH);. (%): C, 67.5; H, 6.3; N, 14.4; S, 11.1. C16H19N3S. (%): C, 67.33; H, 6.71; N, 14.72; S, 11.23.

2-- N --3-(-1-)-2- (17).

, 0.742 (94%). . .. 183-185 . -, ν, (-1): 2175 (C≡N), 2847, 2931 (CH), 3330 (NH). 1 (DMSO- d6, δ, .., J, ): 1.22-1.40 (, 5, 2); 1.63-1.76 (, 3, 2); 1.91-1.95 (, 4, 2); 2.05-2.08 (, 2, 2); 3.72-3.80 (, 4H, 2H2); 4.37-4.39 (, 1, ); 7.72 (, 1H, J =7.9, NH); 8.53 (, 1, ). - (, 70 ), m / z (I (%)): 263 (M+, 35). (%): C, 63.5; H, 8.1; N, 15.8; S, 12.0. C15H17N3S. (%): C, 63.84; H, 8.04; N, 15.95; S, 12.17.

2-- N --3-(-1-)-2- (17). , 0.465 (92%). . .. 213-215. -, ν, -1: 2174 (C≡N); 2850, 2937 (C-H); 3329 (NH). 1 (DMSO- d6, δ, .., J, ): 1.19-1.37 (, 5, 2); 1.59-1.69 (, 9, CH2); 1.90 (, 2, 2); 3.57-3.68 (, 4, 2); 4.35-4.36 (, 1, ); 7.67 (, 1, J = 7.8, NH); 8.38 (, 1, ). (%): C, 65.1; H, 8.6; N, 15.4; S, 11.7. C15H23N3S. (%): C, 64.94; H, 8.36; N, 15.15; S, 11.56.

3-(4-)-2-- N --2- (19). , 0.556 (45%). . .. 174-176. -, ν, -1: 2195 (C≡N);2834, 2909, 2955, 3000, 3058 (C-H); 3297 (NH). 1 (DMSO- d6, δ, .., J, ): 3.04-3.11 (, 3, ); 3.79 (, 3, OMe); 6.89-6.98 (, 2, HAr); 7.25-7.33 (, 2H, HAr); 8.19 8.81( , 1, J= 14.4, ); 8.88- 8.94 (, 1, NH ); 10.38 13.57 ( , 1, J= 14.3, NH). Z- E- 2:3. (%): C, 58.3; H, 5.1; N, 16.8; S, 12.6. C12H13N3OS. (%): C, 58.28; H, 5.30; N, 16.99; S, 12.97.

3-(4-)-2-- N --2- (19). , 1.205 (92%). ... 273-275. 1 (DMSO- d6, δ, .., J, ): 3.12(, 3, J= 4.5, ); 7.53-7.60 (, 2, HAr); 8.20-8.22 (, 2, HAr); 8.55 8.83 ( , 1, J= 12.4, ); 9.34-9.35 (, 1, NH ); 9.35 (., 1, NH ); 10.76 13.69 ( , 1, J= 12.2, NH). Z- E- 1:4. (%): C, 50.2; H, 4.1; N, 21.4; S, 12.1. C16H19N3O2S. (%): C, 50.37; H, 3.84; N, 21.36; S, 12.23.

3-(4-) -2--- N --2- (19). , 0.905 (72%). ... 212-214. -, ν, -1: 2202 (C≡N); 2963, 3035 (C-H); 3281, 3329 (NH). 1 (DMSO- d6, δ, .., J, ): 3.05-3.12 (, 3, ); 7.32-7.40 (, 4H, HAr); 8.35 8.80( , 1, J= 13.2, ); 9.07 (, 1, NH ); 10.49 13.60 ( , 1, J= 13.2, NH). Z- E- 2:3. (%): C, 66.5; H, 4.2; N, 16.3; S, 12.9. C11H10ClN3O. (%): C, 52.48; H, 4.00; N, 16.69; S, 12.74.

3-(4-)-2-(-1-) (19). , 0.674 (47%). ... = 215-217 . 1 (DMSO- d6, δ, .., J, ): 2.02 (, 4, 2); 3.77 (, 3, OMe); 3.83 (, 4, 2); 6.88 7.22 (AA'XX', 4H, J =8.8, HAr); 7.96 8.63 ( , 1, J= 14.4, ); 10.30 11.74 ( , 1, J= 14.4, NH). Z- E- 1:3. (%): C, 66.5; H, 6.1; N, 14.8; S, 11.2. C15H17N3OS. (%): C, 62.69; H, 5.96; N, 14.62; S, 11.16.

3-(4-)-2-(-1-) (19). , 1.011 (67%). ... 200-202. 1 (DMSO- d6, δ, .., J, ): 2.07-2.09 (, 4, 2); 3.80-3.89 (, 4, 2); 7.54 8.20 (AA'XX', 4H, J =9.3, HAr); 8.12 8.60 ( , 1, J= 13.0, ); 10.79-10.72 (, 1, NH). Z- E- 2:3. (%): C, 55.5; H, 4.4; N, 18.4; S, 10.9. C14H14N3O2S. (%): C, 55.61; H, 4.67; N, 18.53; S, 10.61.

2-(-1-)-3-(4-) (19). - , 0.815 (56%). ... 162-164. 1 (DMSO- d6, δ, .., J, ): 2.04-2.06 (, 4, 2); 3.80-3.87 (, 4, 2); 7.31- 7.35 (, 4H, HAr); 8.06 8.61 ( , 1, J= 14.1, ); 10.46 11.24 ( , 1, J= 14.0, NH). Z- E- 1:3. (%): C, 67.8; H, 4.5; N, 14.3; S, 11.7. C14H14ClN3S. (%): C, 57.63; H, 4.84; N, 14.40; S, 10.99.

3-(4-)-2-(-4-) (19). , 1.985 (65%). ... 167-169. -, ν, -1: 2198 (C≡N); 2749, 2836, 2850, 2880, 32964, 2999, 3047, 3085 (C-H); 3194, 3269 (NH). 1 (DMSO- d6, δ, .., J, ): 3.73-3.77 (, 4, 22); 3.78 (, 3, OMe); 3.96-4.00 (, 4, 22); 6.88 7.24 (AA'XX', 4H, J =8.8, HAr); 7.80 8.40 ( , 1, J= 13.6, ); 10.39 10.51 ( , 1, J= 13.2, NH). Z- E- 1:5. (%): C, 60.1; H, 5.7; N, 13.6; S, 10.9. C15H17N3O2S. (%): C, 59.38; H, 5.65; N, 13.85; S, 10.57.

2-(-4-)-3-(4-) (19). , 1.113 (70%). . 70 %. .. 245-247. -, ν, -1: 2205 (C≡N);2859, 2903, 2978, 3023, 3092 (C-H). 1 (DMSO- d6, δ, .., J, ): 3.73-3.76 (, 4, 22); 4.04-4.06 (, 4, 22); 7.50-7.56 (, 2H, HAr); 7.92 8.37 ( , 1, J= 12.9, ); 8.37-8.40 (, 2H, HAr); 10.00 10.80 ( , 1, J= 12.9, NH). Z- E- 2:5. (%): C, 52.5; H, 4.1; N, 17.3; S, 9.9. C14H14N4O3S. (%): C, 52.82; H, 4.43; N, 17.60; S, 10.07.

2-(-4-)-3-(4-) (19). , 1.001 (65%). ... 166-168. -, ν, -1: 2191 (C≡N); 2866, 2903, 2972 (C-H); 3309 (NH). 1 (DMSO- d6, δ, .., J, ): 3.70-3.72 (, 4, 22); 4.01-4.03 (, 4, 22); 7.26- 7.38 (, 4H, HAr); 7.80 8.37 ( , 1, J= 13.2, ); 9.97 10.57 ( , 1, J= 13.4, NH). Z- E- 1:4. , %: C 54.4 H 4.5; N 13.9; S 10.8. C14H14ClN3OS. , %: C 54.63; H 4.58; N 13.65; S 10.42.

⇐ 234567891011 ⇒


:

: 2016-10-06; !; : 390 |

:

:

.
==> ...

1750 - | 1578 -


© 2015-2024 lektsii.org - -

: 0.013 .