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Hardy BG, Shulman KI, Mackenzie SE, et al. Pharmacokinetics of lithium in the elderly. J Clin Psychopharmacol 1987; 7:153.
Vitiello B, Behar D, Malone R, et al. Pharmacokinetics of lithium carbonate in children. J Clin Psychopharmacol 1988; 8:355.
.
Berridge MJ, Downes CP, Hanley MR. Neural and developmental actions of lithium: a unifying hypothesis. Cell 1989; 59:411.
Klein PS, Melton DA. A molecular mechanism for the effect of lithium on development. Proc Natl Acad Sci USA 1996; 93:8455.
Manji HK, Lenox RH. Lithium: a molecular transducer of mood-stabilization in the treatment of bipolar disorder. Neuropsychopharmacology 1998; 19:161.
.
Black DW, Winokur G, Bell S, et al. Complicated mania. Arch Gen Psychiatry 1988; 45:232.
Bowden CL, Brugger AM, Swann AC, et al. Efficacy of divalproex vs. lithium and placebo in the treatment of mania. JAMA 1994; 271:918.
Faedda GL, Tondo L, Baldessarini RJ, et al. Outcome after rapid vs. gradual discontinuation of lithium treatment in bipolar patients. Arch Gen Psychiatry 1993; 50:448.
Gelenberg AJ, Kane JM, Keller MB, et al. Comparison of standard and low serum levels of lithium for maintenance treatment of bipolar disorder. N Engl J Med 1989; 321:1489.
Price LH, Heninger GR. Lithium in the treatment of mood disorders. N Engl J Med 1994; 331:591.
Prien RF, Kupfer DJ, Mansky PA, et al. Drug therapy in the prevention of recurrences in unipolar and bipolar affective disorders. Arch Gen Psychiatry 1984; 41:1096.
Shapiro DR, Quitkin FM, Fleiss JL. Response to maintenance therapy in bipolar illness: effect of an index episode. Arch Gen Psychiatry 1989; 46:401.
Small JG, Klapper MH, Kellams JJ, et al. Electroconvulsive treatment compared with lithium in the management of manic states. Arch Gen Psychiatry 1988; 45:727.
Suppes T, Baldessarini RJ, Faedda GL, et al. Risk of recurrence following discontinuation of lithium treatment in bipolar disorder. Arch Gen Psychiatry 1991; 48:1082.
Varanka TM, Weller RA, Weller EB, et al. Lithium treatment of manic episodes with psychotic features in prepubertal children. Am J Psychiatry 1988; 145:1557.
Bauman P, Nil R, Souche A, et al. A double-blind, placebo-controlled study of citalopram with and without lithium in the treatment of therapy-resistant depressive patients: a clinical, pharmacokinetic, and pharmacogenetic investigation. J Clin Psychopharmacol 1996; 16:307.
De Montigny , Cournoyer G, Morisette R, et al. Lithium cerbonate addition in tricyclic antidepressant-resistant depression: correlation with the neurobiological actions of tricyclic antidepressant drugs and lithium ion on the serotonin system. Arch Gen Psychiatry 1983; 40:1327.
Garbutt JC, Mayo JP Jr, Gillette GM, et al. Lithium potentiation of tricyclic antidepressants following lack of T3 potentiation. Am J Psychiatry 1986; 143:1038.
Heiligenstein MH, Tollefson GD, Faries DE. A double-blind trial of fluoxetine 20 mg and placebo in outpatients with DSM-III-R major depression and melancholia. Int Clin Psychopharmacol 1993; 8:247.
Pope HG, McElroy SL, Nixon RA. Possible synergism between fluoxetine and lithium in refractory depression. Am J Psychiatry 1988; 145:1292.
Price LH, Charney DS, Heninger GR. Variability of response to lithium augmentation in refractory depression. Am J Psychiatry 1986; 143:1387.
|
|
De la Fuente JR, Morse RM, Niven RG, et al. A controlled study of lithium carbonate in the treatment of alcocholism. Mayo Clin Proc 1989; 64:177.
Dorus W, Ostrow DG, Anton R, et al. Lithium treatment of depressed and nondepressed alcoholics. JAMA 1989; 262:1646.
Fawcett J, Clark DC, Aagesen CA, et al. A double-blind, placebo-controlled trial of lithium carbonate therapy for alcocholism. Arch Gen Psychiatry 1987; 44:248.
Shiff HB, Sabin TD, Geller A, et al. Lithium in aggressive behavior. Am J Psychiatry 1982; 139:1346.
Faedda GL, Tondo L, Baldessarini RJ, et al. Outcome after rapid vs. gradual discontinuation of lithium treatment in bipolar disorder. Arch Gen Psychiatry 1993; 50:448.
Kane JM. The role of neuroleptics in manic-depressive illness. J Clin Psychiatry 1988; 49(suppl):12.
Post RM, Roy-Byrne PP, Uhde TW. Graphic representation of the life course of illness in patients with affective disorder. Am J Psychiatry 1988; 145:844.
Shukla S, Mukherjee S, Decina P. Lithium in the treatment of bipolar disorders associated with epilepsy: an open study. J Clin Psychopharmacol 1988; 8:201.
Wehr , Goodwin FK. Rapid cycling in manic-depressives induced by tricyclic antidepressants. Arch Gen Psychiatry 1979; 37:555.
Wehr , Goodwin FK. Can antidepressants cause mania and worsen the course of affective illness? Am J Psychiatry 1987; 144:1403.
Wehr , Sack DA, Rosenthal NE, et al. Rapid cycling affective disorder: contributing factors and treatment responses in 51 patients. Am J Psychiatry 1988; 145:179.
.
Cooper , Simpson GM. The 24-hour lithium level as a prognosticator of dosage requirements: a two-year follow-up study. Am J Psychiatry 1976; 133:440.
Jefferson JW, Greist JH, Clagnaz PJ, et al. Effect of strenuous exercise on serum lithium level in man. Am J Psychiatry 1982; 139:1593.
Perry PJ, Dunner FJ, Hahn RL, et al. Lithium kinetics in single daily dosing. Acta Psychiatr Scand 1981; 64:281.
Post RM, Roy-Byrne PP, Uhde TW. Graphic representation of the life course of illness in patients with affective disorder. Am J Psychiatry 1988; 145:844.