. , , . , . , . - (CDK) () . -CDK. -CDK - , -CDK. , , -CDK2 G1 , G1 S . -CDK2 S G2 , S . . - . , , S , .. G1/S . , , (R-) G1 , , S .
CDK
- (CDK) , , :
1) CDK - , .. , .
2) -CDK . , CDK, CDK (), , CDK7 Mat1.
3) , CDK, ,
, , -CDK.
, Wee1 , Cdc25. (Wee1 Cdc25) , .
4) , -CDK CDK (CKI). CDK INK4 CIP/KIP. INK4 (p15, p16, p18, p19) CDK4 CDK6 , D. CIP/KIP (p21, p27, p57) -CDK, CDK1, CDK2, CDK4 CDK6. , CIP/KIP D-CD4/6
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G1
G1 , (, R-), , . - , . G1 : G1pm ( ) G1ps ( ). G1pm . , G1ps. , G1ps , . G1pm , (G0 ).
, , D-CDK4/6. G1 . , S . D-CDK4/6 (pRb). pRb , , E2F. pRb D-CDK4/6 E2F, , , . G1 , S .
G1 : CDK, , , ,
S
S - , . , , . , 46 , . .
, , G1 S , . , <> , , <>. , ORC (Origin of replicating complex). , , ORC G1 , , <> . G1/S , , , . , , .
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, -CDK2. , S -CDK2, , , , . S .
G2
G2 - , , . G2 -CDK2. G2 -CDK2. G2/ -CDK1, / . .
- . . , , , CDK1. -CDK1 , . , . -CDK1 . -CDK1 , cdc25. , cdc25B cdc25C -CDK1, . , -CDK1 . -CDK1, .