, . miR 124. - (, ) . , . miR9a, , . - miR 124.
: miR 124 , ( ). . ( zebrafish in situ , , ).
, .
miR iso miR
Dicer
:
- 3
- 3 UUUU ( )
.
, - . miR (16%) (ADAR). I C, U. (, ).
:
- ( seed)
- Dicer- . .
: , , , .
genome-wide association studies , pri- 137 ( ), , . 4 miR 137.
miR
: 68, 72.
:
1 , 2 .
VEGF, , . , . 53. . . 53 , VEGF.
miR. . - → Drosha . VEGF .
|
|
53 68 let 7, (, ); 53 , . 53 68, Drosha, .. 53 , 68 let 7.
, , , , .
SMAD, . , - , . Drosha, . moon-lighting , ( moon-lighting).
, , .
, , , . .
:
Let7 , , . . - lin28 ( , let7 ( GGAG)) let7. lin 28 let7 , 3- UUUUUUU → → . Lin28 . .
, . , . let7 c-myc ( ) lin28.
Lin28 (, ) ( (iPSC)). .
.
- (mir signature)
-
- G1, G1-S
- let7 .
- ( Nanog (Nanog ), Oct4 .), .