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REFERENCES
- Brickley-Parsons D, Glimcher MJ. Is the chemistry of collagen in intervertebral discs an expression of Wolffs Law? A study of the human lumbar spine. Spine. 1984;9:14863.PubMed CrossRefGoogle Scholar
- Vanharanta H. The intervertebral disc: a biologically active tissue challenging therapy. Ann Med. 1994;26:3959.PubMed CrossRefGoogle Scholar
- Scott JE, Bosworth TR, Cribb AM, et al. The chemical morphology of age-related changes in human intervertebral disc glycosaminoglycans from cervical, thoracic and lumbar nucleus pulposus and annulus fibrosus. J Anat. 1994;184(Pt 1):7382.PubMed PubMed Central Google Scholar
- Marchand F, Ahmed AM. Investigation of the laminate structure of lumbar disc anulus fibrosus. Spine. 1990;15:40210.PubMed CrossRefGoogle Scholar
- Inoue H. Three-dimensional architecture of lumbar intervertebral discs. Spine. 1981;6:13946.PubMedCrossRefGoogle Scholar
- Wade KR, Robertson PA, Broom ND. A fresh look at the nucleus-endplate region: new evidence for significant structural integration. Eur Spine J. 2011;20:122532. doi:10.1007/s00586-011-1704-y.PubMedPubMed Central CrossRefGoogle Scholar
- Adams MA, Roughley PJ. What is intervertebral disc degeneration, and what causes it? Spine. 2006;31:215161. doi:10.1097/01.brs.0000231761.73859.2c.PubMed CrossRefGoogle Scholar
- Vergroesen P-PA, Kingma I, Emanuel KS, et al. Mechanics and biology in intervertebral disc degeneration: a vicious circle. Osteoarthr Cartil. 2015;23:105770. doi:10.1016/j.joca.2015.03.028.PubMedCrossRefGoogle Scholar
- Urban JPG, Smith S, Fairbank JCT. Nutrition of the intervertebral disc. Spine. 2004;29:27009.PubMedCrossRefGoogle Scholar
- Katz MM, Hargens AR, Garfin SR. Intervertebral disc nutrition. Diffusion versus convection. Clin Orthop. 1986;210:2435.PubMed Google Scholar
- Urban JP, Holm S, Maroudas A, et al. Nutrition of the intervertebral disc: effect of fluid flow on solute transport. Clin Orthop. 1982;170:296302.PubMed Google Scholar
- Urban JP, Holm S, Maroudas A. Diffusion of small solutes into the intervertebral disc: as in vivo study. Biorheology. 1978;15:20321.PubMed Google Scholar
- Bayliss MT, Urban JP, Johnstone B, et al. In vitro method for measuring synthesis rates in the intervertebral disc. J Orthop Res. 1986;4:107. doi:10.1002/jor.1100040102.PubMed CrossRefGoogle Scholar
- Ohshima H, Tsuji H, Hirano N, et al. Water diffusion pathway, swelling pressure, and biomechanical properties of the intervertebral disc during compression load. Spine. 1989;14:123444.PubMedCrossRefGoogle Scholar
- Ohshima H, Urban JP, Bergel DH. Effect of static load on matrix synthesis rates in the intervertebral disc measured in vitro by a new perfusion technique. J Orthop Res. 1995;13:229. doi:10.1002/jor.1100130106.PubMed CrossRefGoogle Scholar
- McMillan DW, Garbutt G, Adams MA. Effect of sustained loading on the water content of intervertebral discs: implications for disc metabolism. Ann Rheum Dis. 1996;55:8807.PubMed PubMed CentralCrossRefGoogle Scholar
- Arun R, Freeman BJC, Scammell BE, et al. 2009 ISSLS Prize Winner: what influence does sustained mechanical load have on diffusion in the human intervertebral disc?: an in vivo study using serial postcontrast magnetic resonance imaging. Spine. 2009;34:232437. doi:10.1097/BRS.0b013e3181b4df92.PubMed CrossRefGoogle Scholar
- Das DB, Welling A, Urban JPG, et al. Solute transport in intervertebral disc: experiments and finite element modeling. Ann N Y Acad Sci. 2009;1161:4461. doi:10.1111/j.1749-6632.2008.04075.x.PubMedCrossRefGoogle Scholar
- Ferguson SJ, Ito K, Nolte LP. Fluid flow and convective transport of solutes within the intervertebral disc. J Biomech. 2004;37:21321.PubMed CrossRefGoogle Scholar
- De Puky P. The physiological oscillation of the length of the body. Acta Orthop. 1935;6:33847.CrossRefGoogle Scholar
- Ahrens SF. The effect of age on intervertebral disc compression during running. J Orthop Sports Phys Ther. 1994;20:1721. doi:10.2519/jospt.1994.20.1.17.PubMed CrossRefGoogle Scholar
- Carrigg SY, Hillemeyer LE, Villanueva EE. The effect of running-induced intervertebral disc compression on thoracolumbar vertebral column mobility in young, healthy males. J Orthop Sports Phys Ther. 1992;16:1924. doi:10.2519/jospt.1992.16.1.19.PubMed CrossRefGoogle Scholar
- Dowzer CN, Reilly T, Cable NT. Effects of deep and shallow water running on spinal shrinkage. Br J Sports Med. 1998;32:448.PubMed PubMed Central CrossRefGoogle Scholar
- White TL, Malone TR. Effects of running on intervertebral disc height. J Orthop Sports Phys Ther. 1990;12:13946.PubMed CrossRefGoogle Scholar
- Boocock MG, Garbutt G, Linge K, et al. Changes in stature following drop jumping and post-exercise gravity inversion. Med Sci Sports Exerc. 1990;22:38590.PubMed CrossRefGoogle Scholar
- Fowler NE, Lees A, Reilly T. Spinal shrinkage in unloaded and loaded drop-jumping. Ergonomics. 1994;37:1339. doi:10.1080/00140139408963631.PubMed CrossRefGoogle Scholar
- Leatt P, Reilly T, Troup JG. Spinal loading during circuit weight-training and running. Br J Sports Med. 1986;20:11924.PubMed PubMed Central CrossRefGoogle Scholar
- Reilly T, Freeman KA. Effects of loading on spinal shrinkage in males of different age groups. Appl Ergon. 2006;37:30510. doi:10.1016/j.apergo.2005.07.004.PubMed CrossRefGoogle Scholar
- Tyrrell AR, Reilly T, Troup JD. Circadian variation in stature and the effects of spinal loading. Spine. 1985;10:1614.PubMed CrossRefGoogle Scholar
- Van Dieën JH, Creemers M, Draisma I, et al. Repetitive lifting and spinal shrinkage, effects of age and lifting technique. Clin Biomech Bristol Avon. 1994;9:36774. doi:10.1016/0268-0033(94)90067-1.CrossRefGoogle Scholar
- Malko JA, Hutton WC, Fajman WA. An in vivo magnetic resonance imaging study of changes in the volume (and fluid content) of the lumbar intervertebral discs during a simulated diurnal load cycle. Spine. 1999;24:101522.PubMed CrossRefGoogle Scholar
- Malko JA, Hutton WC, Fajiman WA. An in vivo study of the changes in volume (and fluid content) of the lumber intervertebral disc after overnight bed rest and during an 8-hour walking protocol. J Spinal Disord Tech. 2002;15:15763.PubMed CrossRefGoogle Scholar
- Dimitriadis AT, Papagelopoulos PJ, Smith FW, et al. Intervertebral disc changes after 1 h of running: a study on athletes. J Int Med Res. 2011;39:56979.PubMed CrossRefGoogle Scholar
- Kingsley MI, DSilva LA, Jennings C, et al. Moderate-intensity running causes intervertebral disc compression in young adults. Med Sci Sports Exerc. 2012;44:2199204. doi:10.1249/MSS.0b013e318260dbc1.PubMedCrossRefGoogle Scholar
- Botsford DJ, Esses SI, Ogilvie-Harris DJ. In vivo diurnal variation in intervertebral disc volume and morphology. Spine. 1994;19:93540.PubMed CrossRefGoogle Scholar
- Hellström M, Jacobsson B, Swärd L, et al. Radiologic abnormalities of the thoraco-lumbar spine in athletes. Acta Radiol. 1990;31:12732.PubMed CrossRefGoogle Scholar
- Granhed H, Morelli B. Low back pain among retired wrestlers and heavyweight lifters. Am J Sports Med. 1988;16:5303.PubMed CrossRefGoogle Scholar
- Swärd L, Hellstrom M, Jacobsson B, et al. Back pain and radiologic changes in the thoraco-lumbar spine of athletes. Spine. 1990;15:1249.PubMed CrossRefGoogle Scholar
- Nagashima M, Abe H, Amaya K, et al. Risk factors for lumbar disc degeneration in high school American football players: a prospective 2-year follow-up study. Am J Sports Med. 2013;41:205964. doi:10.1177/0363546513495173.PubMed CrossRefGoogle Scholar
- Brüggemann G-P, Krahl H. Belastungen und Risiken im weiblichen Kunstturnen. Teil 1, Aus der Sicht von Biomechanik und Sportmedizin [Loading and risks in female gymnasts. Part 1, biomechanics and sports medicine]. Schorndorf: Hofmann; 2000.
- Ranson CA, Kerslake RW, Burnett AF, et al. Magnetic resonance imaging of the lumbar spine in asymptomatic professional fast bowlers in cricket. J Bone Joint Surg Br. 2005;87:11116. doi:10.1302/0301-620X.87B8.16405.PubMed CrossRefGoogle Scholar
- Videman T, Battié MC, Gibbons LE, et al. Lifetime exercise and disk degeneration: an MRI study of monozygotic twins. Med Sci Sports Exerc. 1997;29:13506.PubMed CrossRefGoogle Scholar
- Maurer M, Soder RB, Baldisserotto M. Spine abnormalities depicted by magnetic resonance imaging in adolescent rowers. Am J Sports Med. 2011;39:3927. doi:10.1177/0363546510381365.PubMedCrossRefGoogle Scholar
- Kraft CN, Pennekamp PH, Becker U, et al. Magnetic resonance imaging findings of the lumbar spine in elite horseback riders: correlations with back pain, body mass index, trunk/leg-length coefficient, and riding discipline. Am J Sports Med. 2009;37:220513. doi:10.1177/0363546509336927.PubMedCrossRefGoogle Scholar
- Bartolozzi C, Caramella D, Zampa V, et al. The incidence of disk changes in volleyball players. The magnetic resonance findings [in Italian]. Radiol Med. 1991;82:75760.PubMed Google Scholar
- Goldstein JD, Berger PE, Windler GE, et al. Spine injuries in gymnasts and swimmers. An epidemiologic investigation. Am J Sports Med. 1991;19:4638.PubMed CrossRefGoogle Scholar
- Hangai M, Kaneoka K, Hinotsu S, et al. Lumbar intervertebral disk degeneration in athletes. Am J Sports Med. 2009;37:14955. doi:10.1177/0363546508323252.PubMed CrossRefGoogle Scholar
- Kaneoka K, Shimizu K, Hangai M, et al. Lumbar intervertebral disk degeneration in elite competitive swimmers: a case control study. Am J Sports Med. 2007;35:13415. doi:10.1177/0363546507300259.PubMedCrossRefGoogle Scholar
- Videman T, Sarna S, Battié MC, et al. The long-term effects of physical loading and exercise lifestyles on back-related symptoms, disability, and spinal pathology among men. Spine. 1995;20:699709.PubMedCrossRefGoogle Scholar
- Videman T, Nurminen M, Troup JD. 1990 Volvo Award in clinical sciences. Lumbar spinal pathology in cadaveric material in relation to history of back pain, occupation, and physical loading. Spine. 1990;15:72840.PubMed Google Scholar
- Kordi M, Belavý DL, Armbrecht G, et al. Loss and re-adaptation of lumbar intervertebral disc water signal intensity after prolonged bedrest. J Musculoskelet Neuronal Interact. 2015;15:294300.PubMed Google Scholar
- Hangai M, Kaneoka K, Kuno S, et al. Factors associated with lumbar intervertebral disc degeneration in the elderly. Spine J. 2008;8:73240. doi:10.1016/j.spinee.2007.07.392.PubMed CrossRefGoogle Scholar
- Adams MA, Hutton WC. Prolapsed intervertebral disc. A hyperflexion injury. 1981 Volvo Award in Basic Science. Spine. 1982;1982(7):18491.CrossRefGoogle Scholar
- Wade KR, Robertson PA, Thambyah A, et al. How healthy discs herniate: a biomechanical and microstructural study investigating the combined effects of compression rate and flexion. Spine. 2014;39:101828. doi:10.1097/BRS.0000000000000262.PubMed CrossRefGoogle Scholar
- Roaf R. A study of the mechanics of spinal injuries. J Bone Joint Surg Br. 1960;42:81023.Google Scholar
- Wang Y, Videman T, Battié MC. ISSLS prize winner: lumbar vertebral endplate lesions: associations with disc degeneration and back pain history. Spine. 2012;37:14906. doi:10.1097/BRS.0b013e3182608ac4.PubMedCrossRefGoogle Scholar
- Holm S, Holm AK, Ekström L, et al. Experimental disc degeneration due to endplate injury. J Spinal Disord Tech. 2004;17:6471.PubMed CrossRefGoogle Scholar
- Schmidt H, Heuer F, Wilke H-J. Dependency of disc degeneration on shear and tensile strains between annular fiber layers for complex loads. Med Eng Phys. 2009;31:6429. doi:10.1016/j.medengphy.2008.12.004.PubMedCrossRefGoogle Scholar
- Adams MA, Hutton WC. Gradual disc prolapse. Spine. 1985;10:52431.PubMed CrossRefGoogle Scholar
- Hansson TH, Keller TS, Spengler DM. Mechanical behavior of the human lumbar spine. II. Fatigue strength during dynamic compressive loading. J Orthop Res. 1987;5:47987. doi:10.1002/jor.1100050403.PubMedCrossRefGoogle Scholar
- Holm S, Nachemson A. Variations in the nutrition of the canine intervertebral disc induced by motion. Spine. 1983;8:86674.PubMed CrossRefGoogle Scholar
- Säämänen AM, Puustjärvi K, Ilves K, et al. Effect of running exercise on proteoglycans and collagen content in the intervertebral disc of young dogs. Int J Sports Med. 1993;14:4851. doi:10.1055/s-2007-1021145.PubMedCrossRefGoogle Scholar
- Brisby H, Wei AQ, Molloy T, et al. The effect of running exercise on intervertebral disc extracellular matrix production in a rat model. Spine. 2010;35:142936. doi:10.1097/BRS.0b013e3181e0f5bc.PubMedCrossRefGoogle Scholar
- Sasaki N, Henriksson HB, Runesson E, et al. Physical exercise affects cell proliferation in lumbar intervertebral disc regions in rats. Spine. 2012;37:14407. doi:10.1097/BRS.0b013e31824ff87d.PubMedCrossRefGoogle Scholar
- Puustjärvi K, Lammi M, Kiviranta I, et al. Proteoglycan synthesis in canine intervertebral discs after long-distance running training. J Orthop Res. 1993;11:73846. doi:10.1002/jor.1100110516.PubMedCrossRefGoogle Scholar
- Puustjärvi K, Lammi M, Helminen H, et al. Proteoglycans in the intervertebral disc of young dogs following strenuous running exercise. Connect Tissue Res. 1994;30:22540.PubMed CrossRefGoogle Scholar
- Puustjärvi K, Takala T, Wang W, et al. Enhanced prolylhydroxylase activity in the posterior annulus fibrosus of canine intervertebral discs following long-term running exercise. Eur Spine J. 1993;2:12631.PubMedCrossRefGoogle Scholar
- Neufeld JH. Induced narrowing and back adaptation of lumbar intervertebral discs in biomechanically stressed rats. Spine. 1992;17:8116.PubMed CrossRefGoogle Scholar
- Cassidy JD, Yong-Hing K, Kirkaldy-Willis WH, et al. A study of the effects of bipedism and upright posture on the lumbosacral spine and paravertebral muscles of the Wistar rat. Spine. 1988;13:3018.PubMedCrossRefGoogle Scholar
- Higuchi M, Abe K, Kaneda K. Changes in the nucleus pulposus of the intervertebral disc in bipedal mice. A light and electron microscopic study. Clin Orthop. 1983;175:2517.PubMed Google Scholar
- Yamada K. The dynamics of experimental posture. Experimental study of intervertebral disk herniation in bipedal animals. Clin Orthop. 1962;25:2031.PubMed Google Scholar
- Chan SCW, Ferguson SJ, Gantenbein-Ritter B. The effects of dynamic loading on the intervertebral disc. Eur Spine J. 2011;20:1796812. doi:10.1007/s00586-011-1827-1.PubMed PubMed Central CrossRefGoogle Scholar
- Iatridis JC, MacLean JJ, Roughley PJ, et al. Effects of mechanical loading on intervertebral disc metabolism in vivo. J Bone Joint Surg Am. 2006;88(Suppl 2):416.PubMed PubMed Central CrossRefGoogle Scholar
- Le Maitre CL, Frain J, Fotheringham AP, et al. Human cells derived from degenerate intervertebral discs respond differently to those derived from non-degenerate intervertebral discs following application of dynamic hydrostatic pressure. Biorheology. 2008;45:56375.PubMed Google Scholar
- Wilke HJ, Neef P, Caimi M, et al. New in vivo measurements of pressures in the intervertebral disc in daily life. Spine. 1999;24:75562.PubMed CrossRefGoogle Scholar
- Mayer JE, Iatridis JC, Chan D, et al. Genetic polymorphisms associated with intervertebral disc degeneration. Spine J. 2013;13:299317. doi:10.1016/j.spinee.2013.01.041.PubMed PubMed CentralCrossRefGoogle Scholar
- Elfering A, Semmer N, Birkhofer D, et al. Risk factors for lumbar disc degeneration: a 5-year prospective MRI study in asymptomatic individuals. Spine. 2002;27:12534.PubMed CrossRefGoogle Scholar
- Yuan H-Y, Tang Y, Liang Y-X, et al. Matrix metalloproteinase-3 and vitamin d receptor genetic polymorphisms, and their interactions with occupational exposure in lumbar disc degeneration. J Occup Health. 2010;52:2330.PubMed CrossRefGoogle Scholar
- Coventry MB. Anatomy of the intervertebral disk. Clin Orthop. 1969;67:915.PubMed CrossRefGoogle Scholar
- Kraemer J, Kolditz D, Gowin R. Water and electrolyte content of human intervertebral discs under variable load. Spine. 1985;10:6971.PubMed CrossRefGoogle Scholar
- Koeller W, Muehlhaus S, Meier W, et al. Biomechanical properties of human intervertebral discs subjected to axial dynamic compressioninfluence of age and degeneration. J Biomech. 1986;19:80716.PubMedCrossRefGoogle Scholar
- Sether LA, Yu S, Haughton VM, et al. Intervertebral disk: normal age-related changes in MR signal intensity. Radiology. 1990;177:3858. doi:10.1148/radiology.177.2.2217773.PubMed CrossRefGoogle Scholar
- Boos N, Weissbach S, Rohrbach H, et al. Classification of age-related changes in lumbar intervertebral discs: 2002 Volvo Award in basic science. Spine. 2002;27:263144. doi:10.1097/01.BRS.0000035304.27153.5B.PubMed CrossRefGoogle Scholar
- Luoma K, Vehmas T, Riihimäki H, et al. Disc height and signal intensity of the nucleus pulposus on magnetic resonance imaging as indicators of lumbar disc degeneration. Spine. 2001;26:6806.PubMedCrossRefGoogle Scholar
- Sivan SS, Wachtel E, Roughley P. Structure, function, aging and turnover of aggrecan in the intervertebral disc. Biochim Biophys Acta. 2014;1840:31819. doi:10.1016/j.bbagen.2014.07.013.PubMedCrossRefGoogle Scholar
- MacKelvie KJ, Khan KM, McKay HA. Is there a critical period for bone response to weight-bearing exercise in children and adolescents? A systematic review. Br J Sports Med. 2002;36:2507 (discussion 257). PubMedPubMed Central CrossRefGoogle Scholar
- Ledsome JR, Lessoway V, Susak LE, et al. Diurnal changes in lumbar intervertebral distance, measured using ultrasound. Spine. 1996;21:16715.PubMed CrossRefGoogle Scholar
- Wang Y-XJ, Griffith JF, Leung JCS, et al. Age related reduction of T1rho and T2 magnetic resonance relaxation times of lumbar intervertebral disc. Quant Imaging Med Surg. 2014;4:25964. doi:10.3978/j.issn.2223-4292.2014.07.14.PubMed PubMed Central Google Scholar
- VanTulder MW, Assendelft WJ, Koes BW, et al. Spinal radiographic findings and nonspecific low back pain. A systematic review of observational studies. Spine. 1997;22:42734.CrossRefGoogle Scholar
- Boden SD, McCowin PR, Davis DO, et al. Abnormal magnetic-resonance scans of the cervical spine in asymptomatic subjects. A prospective investigation. J Bone Joint Surg Am. 1990;72:117884.PubMedGoogle Scholar
- Boden SD, Davis DO, Dina TS, et al. Abnormal magnetic-resonance scans of the lumbar spine in asymptomatic subjects. A prospective investigation. J Bone Joint Surg Am. 1990;72:4038.PubMed Google Scholar
- Vernon-Roberts B, Pirie CJ. Degenerative changes in the intervertebral discs of the lumbar spine and their sequelae. Rheumatol Rehabil. 1977;16:1321.PubMed CrossRefGoogle Scholar
- Pfirrmann CW, Metzdorf A, Zanetti M, et al. Magnetic resonance classification of lumbar intervertebral disc degeneration. Spine. 2001;26:18738.PubMed CrossRefGoogle Scholar
- Belavý DL, Armbrecht G, Gast U, et al. Countermeasures against lumbar spine deconditioning in prolonged bed-rest: resistive exercise with and without whole-body vibration. J Appl Physiol. 2010;109:180111.PubMedCrossRefGoogle Scholar
- An HS, Anderson PA, Haughton VM, et al. Introduction: disc degeneration: summary. Spine. 2004;29:26778.PubMed CrossRefGoogle Scholar
- Marinelli NL, Haughton VM, Munoz A, et al. T2 relaxation times of intervertebral disc tissue correlated with water content and proteoglycan content. Spine. 2009;34:5204.PubMed CrossRefGoogle Scholar
- Weidenbaum M, Foster RJ, Best BA, et al. Correlating magnetic resonance imaging with the biochemical content of the normal human intervertebral disc. J Orthop Res. 1992;10:55261. doi:10.1002/jor.1100100410.PubMed CrossRefGoogle Scholar <