Scott A. Harper (Chairman; CDC; New York, NY; and Atlanta, GA), John S. Bradley (Rady Children’s Hospital and the University of California San Diego School of Medicine and Children’s Hospital and Health Center), Janet A. Englund (University of Washington School of Medicine and Seattle Children’s Hospital; Seattle), Thomas M. File (Summa Health System and Northeastern Ohio Universities Colleges of Medicine & Pharmacy; Akron), Stefan Gravenstein (Alpert Medical School of Brown University and Quality Partners of Rhode Island; Providence, RI), Frederick G. Hayden (University of Virginia School of Medicine; Charlottesville), Allison J. McGeer (University of Toronto and Mt. Sinai Hospital; Toronto, Ontario, Canada), Kathleen M. Neuzil (University of Washington School of Medicine and Program for Appropriate Technology in Health; Seattle), Andrew T. Pavia (University of Utah School of Medicine and Primary Children’s Hospital; Salt Lake City), Michael L. Tapper (Lenox Hill Hospital; New York), Timothy M. Uyeki (CDC; Atlanta, GA), and Richard K. Zimmerman (University of Pittsburgh School of Medicine; Pittsburgh, PA).
Подяка
Експертна група хотіла б висловити свою вдячність Kathryn Edwards, William P. Gleazen, Isaac Weisfuse, Marci Layton, Annie Fine, Carolyn Bridges, Joe Bresee, Anthony Fiore, Beth Nivin і Jennifer Padberg за їх рецензування проекту документу.
Фінансування. IDSA.
Потенційні конфлікти інтересів. J.A.E. отримав грант/підтримку дослідження від Sanofi Pasteur та MedImmune, працює доповідачем для Sanofi Pasteur та є консультантом Sanofi Pasteur, Roche, Novartis та GlaxoSmithKline. T.M.F. отримав грант/підтримку дослідження від Cerexa, Ortho-McNeil та Pfizer; був консультантом для Advanced Life Sciences, Forrest, Ortho-McNeil, Merck, Nabriva, Oscient, Pfizer, Schering Plough и Wyeth; є доповідачем для Merck, Ortho-McNeil, Oscient, Pfizer, Schering Plough та Wyeth. K.M.N. є співробітником Консультативної ради з імунізації дорослих при Американскому коледжі лікарів. M.L.T. був доповідачем на засіданні Безперервної Медичної Освіти, спонсором якого були Roche та Gilead. S.G. має угоду на послуги консультанта з Juvaris, GlaxoSmithKline, Sanofi Pasteur и Merck; працює доповідачем для GlaxoSmithKline. A.T.P. є консультантом для NexBio та GlaxoSmithKline. A.J.M. отримав грант/підтримку дослідження від Roche та GlaxoSmithKline; був доповідачем та консультантом для Sanofi Pasteur, Gilead Biosciences та Bioсryst Pharmaceuticals. R.K.Z. виступає в якості консультанта для MedImmune. Всі інші автори: не мали конфлікту інтересів.
Глосарій
| Ангіна | В даній настанові термін ангіна (англ. Quincy) маэ наступну дефініцію: гостре бактеріальне захворювання, яке, як правило, є ускладненням гострого тонзиліту, в основі має гнійно-рідке запалення (абсцесс) піднебінного мигдалика і часто супроводжується больовим синдромом. |
| Внутрішня валідність | Властивість наукових досліджень, яка відображає в якій мірі виправданий висновок про причини (випливає з результатів наукового дослідження); відображає в якій мірі мінімізована систематична помилка. |
| Заклади закритого типу | Організовані колективи, що пов’язані із закладом, установою (англ. institutional). |
| ЗТ-ПЛР | Метод полімеразної ланцюгової реакції ампліфікації послідовності нуклеїнових кислот, в якому використовується РНК в якості шаблону для розшифровки відповідної ДНК з використанням зворотньої транскриптази (англ. RT-PCR). |
| Літні люди | Особи віком старше 65 років, які мають функціональні порушення органів та/чи систем, або особи старше 75 років (англ. elderly persons). |
| Немовлята | Термін застосовується до дітей віком до 1 року (англ. infants). |
| Проспективне дослідження (випробовування) | Дослідження (випробовування), в якому група формується сьогодні, а досліджується в майбутньому (групу спостереження формують до того, як отримано результати). Головною перевагою проспективних досліджень є повна визначеність групи, що спостерігається, станів, що виявляються, методів дослідження та інших деталей до початку клінічного дослідження. |
| Самообмежувальні хвороби | Хвороби, що тривають певний строк та можуть завершитися без лікування (англ. self-limited). |
| Співвідношення шансів (СШ) | Відношення кількості учасників дослідження, у яких виявлено той чи інший клінічний результат, до кількості учасників дослідження, у яких даного результату не виявлено (не було досягнуто). В більшості випадків СШ та відносний ризик (ВР) приблизно однакові, через це багато хто, фактично розраховуючи СШ, надають результати у вигляді ВР. Іноді це може призводити до помилкових висновків. |
| Шкала Бріза | Шкала призначена для оцінки імовірності БГСА-фарингіту у дітей. Шкала була розробленя B.B.Breese в 1977 році. Шкала включає місяць року, вік пацієнта, кількість лейкоцитів в крові, симптоми (гарячка, біль в горлі, кашель, головний біль), зміни в глотці, зміни в шийних лімфовузлах. Кожному показнику відповідають певні бали. Набраним балам відповідають певні відсотки імовірності у пацієнта БГСА-фарингіту. |
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