Наиболее важные лекарственные взаимодействия представлены в таблице 3.11.
Таблица 3.11. Взаимодействие ингибиторов моноаминооксидазы с другими препаратами a
| Препарат | Эффекты |
| Симпатомиметики (амфетамины, дофамин, эфедрин, адреналин, изопротеренол (Изупрел), метараминол, метилфенидат, оксиметазолин (Африн), норадреналин, фенилэфрин (Нео-синефрин), фенилпропаноламин, псевдоэфедрин (Судафед)) | Гипертонический криз |
| Меперидин (Демерол и др.) | Лихорадка, делирий, гипертензия, гипотензия, повышение нервно-мышечной возбудимости, смерть |
| Пероральные антидиабетические средства | Дополнительное снижение сывороточной глюкозы |
| L-допа | Гипертонический криз |
| Трициклические антидепрессантыb, венлафаксинc | Лихорадка, судорожные припадки, делирий |
| СИОЗС, кломипрамин, триптофан | Тошнота, спутанность сознания, тревога, озноб, гипертермия, мышечная ригидность, потливость, гиперрефлексия, тахикардия, гипотензия, кома, смерть |
| Бупропион | Гипертонический криз |
a — Это взаимодействие может происходить при использовании селегилина даже в низких дозах.
b — Трициклические антидепрессанты и ИМАО иногда применяются совместно.
с — Схожий эффект.
Литература.
Механизм действия.
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Показания.
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Применение.
Fontaine R, Ontiveros H, Elie R, et al. A double-blind comparison of nefazodone, imipramine, and placebo in major depression. J Clin Psychiatry 1994; 55:234.
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Побочные эффекты.
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Передозировка.
Barbey JT, Roose SP. SSRI safety in overdose. J Clin Psychiatry 1998; 59(suppl 15):45.
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