, / .
70- , (. 9.2) , - (, 1975).
. . . , . ( ) , . , , , , (Wimer et al., 1971). , , .
, ( , - ) (. . ). , , . . . , , , ( ) .
. 9.2. iipMF .
; iipMF;
: , , , ; : , 5- , ( ) iipMF, (: Lipp, Wolfer. 1995).
(. . ) . (. 3.2.2). (.: Li etal., 1989; Schwegler, Lipp, 1995). , (. 9.2). . , . . . . . , , . - , iipMF. ( ) . (. ), , iipMF . , DBA/2J, / ( . 9.2 ), (-0,92) UpMFn . , . iipMF .
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, , iipMF.
, , . . , .
iipMF (. 3.4.2.1), ( , . 3.4). iipMF (Schwegler, Lipp, 1995). . 9.2 , . (. ). ( , . 3.4.2.2), , , iipMF (Schwegler, Lipp, 1995).
, .
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( iipMF), , . . , (Schwegler, Lipp, 1995).
, , ( ) , / .
, . -. Lipp, Wolfer (1998), BehavioralPhenotypingofMouseMutants (Cologne, 2000).
. . , . , , , . ( ) . , , , (, ), , - (.: , 1987; Jones, Mormede, 1999).
. . . , ( ) , . ( ), ( ) . , ( ). .
- . , .
- , , - . , . . , () , -, , . - , .
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, .
, , - . , , () . , . .
. (long term potentiation, LTP).
LTP (. . ), ( 1) , (. . ).
, , . . invitro. , . ( ) :
NMDA- (. . , ---, ~ , );
(^), ( - .);
(- , ^- II ).
LTP - , , , . g .
, . . , iipMF.
I) MKII , , , . . (. 3.4).
510 (. . -, , ) LTP , . LTP.
, - . , . (Mayford et al., 1995).
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NMDA- 2 ( LTP).
(freezing response) , . . , : NMDA- ( , ) , , .
, .
, :
* , ;
* .
, ().
, . , , . . . , , , . ( , , ) .
- , CREB (Bourchaladze et al., 1994). CREB (c-AMPresponseelementbindingprotein) , - .
- CREB (30 60 ). , ( 2 ), .
, (LTP) , CREB, . 2 , LTP, , .
, , , CREB, , , .