|
-
|
| .
| |
|
| | +
|
| |
| | ()
|
| | ()
|
| | (-)
|
| |
|
| |
|
| | ()
|
| | -
|
| | -
|
| |
|
| | ()
|
| | -1-2 ()
|
| | ()
|
| | -
|
| | ( )
|
| |
|
| |
| |
|
| |
|
| |
|
| |
|
| | ()
|
| |
|
| | ( )
|
| |
| |
|
| |
|
| |
|
| | ()
|
| | - (
:-,-
)
|
| | - :
:-,- -
(-
) + ;
IgG,IgM,IgA
|
| |
|
| |
|
| | (1)
|
| |
|
| | (
, 1 2 )
|
| | (-
,, - 2
)
|
| | ( )
|
| |
|
| |
|
| |
|
| | (,HDL)
|
| | (,LDL)
|
| | (),Lp()
|
| | 1
|
| |
|
| |
|
| |
|
| | ,,(+,Na+,Cl-)
|
| | (Ca++)
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
()
|
| |
|
| |
|
| |
|
| | 12()
|
| | ()
|
| | 25- D OH(25-)
|
| |
|
| | - ()
|
| | (-)
|
| |
|
| | -1-
|
| | -1-
|
| |
|
| |
|
| |
|
| |
|
| | -2-
|
| | -2-
|
| | 3
|
| | 4
|
| | -
|
| | -
|
| | G (lgG)
|
| | (lgM)
|
| | (lgA)
|
| | (lgE)
|
| |
|
| | -
|
| | (
, )
|
| | ( , )
|
| | -
|
| | NT-BNP (N-
)
|
| | l
|
| |
|
| |
| | ( ) +
|
| |
|
| |
|
| |
|
| | III
|
| | D-
|
| | S
|
| |
|
| |
|
| |
| |
|
| | ( )
|
| | 4
|
| | 3
|
| | (-)
|
| | (-)
|
| |
|
| |
|
| | 4
|
| | 3
|
| |
|
| |
|
| |
|
| | ()
|
| | ()
|
| | (2)
|
| |
|
| | 17--
|
| |
|
| | (\IS)
|
| |
|
| | , (SHBG)
|
| |
|
| |
|
| |
|
| | ()
|
| | (3)
|
| |
(-)
|
| |
|
| |
|
| | (1
: 11-13 )
|
| | 1-
(11-13 ): PAPP-A, β-(
); + -
,( )
|
| | (2
: 16-21 )
|
| | 2-
16-21 ):- (),-
(), -
(3); +
( )
|
| |
|
| |
|
| | - (-)
|
| | ()
|
| |
|
| |
|
| |
|
| | ( )
|
| | /
|
| |
|
| |
|
| | -
|
| | -
|
| | (GAD)
|
| |
|
| |
|
| |
|
| | -17
|
| | -17
|
| | -1
|
| | -2
|
| | ( ):
-17 ,-1,-
-2, Helicobacter pylori (.),-
|
| | -
, -
, , )
( ,):
, ,
ASCA-AT k Saccharomyces cereviviae
|
| |
()
|
| | ()
|
| |
|
| | ( )
|
| |
|
| | - (β-Cross Laps)
|
| | P1NP
(N- 1 )
|
| | (P)
( ;
)
|
| |
|
| | ()
|
| | 1(-1;
)
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| | ()
|
| |
| | -()
|
| |
( )
|
| | -
( )
|
| | - ()
|
| | (SCC)
|
| | 125
|
| | -4
|
| |
(4 + 125)
|
| | 15-3
|
| | 72-4
|
| | 242
|
| | 19-9
|
| | ()
|
| |
|
| |
|
| | Cyfra-21-1
|
| | (NSE)
|
| | -2-
|
| |
|
| | S-100
|
| | ( )
|
| |
|
| | (
): lgG,lgM,lgA,
lgE;
();
(.)
|
| | ( )
| | -
( ): -(
1,2+), Treponema pallidum (lgG+lgM),
HBsAg( ), (-
HCV,)
|
| | TORCH-( ):
Toxoplasma gondii lgG ( lgG),
Toxoplasma gondii lgM ( lgM),
Rubella lgG ( lgG), Rubella lgM ( lgM),CMV lgG (
lgG), CMV lgM ( lgM), Herpes 2 lgG(
2 lgG), Herpes 1 lgG(
1 lgG), Herpes (1+2)
lgM( 1 2 lgM)
|
| |
| | -(HIV)
|
| | - (HIV):
1,2 +
|
| | (HAV)
|
| | lgM (-HAV lgM)
|
| | (-HAV)
|
| | (HBV)
|
| | HBsAg ( s )
|
| | -HBS ( s
, -HBs)
|
| | -HBc ( ,-HBc)
|
| | -HBc lgM ( , -HBc lgM)
|
| | HBeAg ( )
|
| | -Hbe (
, -HBe
|
| | (HCV)
|
| | (-HCV, )
|
| | lgM (-HCV lgM)
|
| | lgG-
|
| | D (,HDV)
|
| | D (-HDV)
|
| | D lgM (-HDV lgM)
|
| | (HEV)
|
| | lgG (-HEV lgG)
|
| | lgM(-HEV lgM)
|
| | 1 2 (Herpes 1&2,-1,2)
| | 2 lgG (Herpes
(HSV)2 lgG)
|
| | 1 lgG (Herpes
(HSV) 1 lgG)
|
| | 1 2 lgM
(Herpes (HSV)1+2 lgM)
|
| | (MV, HHV-5, ,
)
|
| | lgG (CMV lgG)
|
| | lgM (CMV lgM)
|
| | lgG (CMV
lgG Avidity)
|
| | - (Epstein-Barr virus(EBV),
HHV-4, ,
|
| | -
lgG (EBV VCAlgG)
|
| | -
lgM (EBV VCAlgM)
|
| | -
lgG (EBV NAlgG)
|
| | - lgG (.)
|
| | - (Varicella-zoster virus(VZV), HHV-3, , )
| | - lgG(.)
|
| | - lgM (.)
|
| | (Rubella; Rubivirus
|
| | lgG
|
| | lgM)
|
| | (Measies virus)
|
| | lgG
|
| | (Mumps virus, )
| | lgG
|
| | lgM
|
| | 19 (Parvovirus B19,
)
| | 19 lgG
|
| | 19 lgM
|
| |
|
| | lgG
|
| | lgM
|
| | (Trponema pallidum ( ))
| | Treponema pallidum (lgG+lgM)
|
| | Treponema pallidum lgM
|
| | A Treponema pallidum (; )
|
| |
(RRR)
|
| |
| |
|
| | Chlamydia trachomatis lgG
|
| | Chlamydia trachomatis lgA
|
| | Chlamydia trachomatis lgM
|
| | Mycoplasma hominis lgG
|
| | Mycoplasma hominis lgA
|
| | Ureaplasma urealitycum lgG
|
| | Ureaplasma urealitycum lgA
|
| |
|
| | Chlamydia pneumoniae lgG
|
| | Chlamydia pneumoniae lgA
|
| | Chlamydia pneumoniae lgM
|
| | Mycoplasma pneumoniae lgG
|
| | Mycoplasma pneumoniae lgA
|
| | Mycoplasma pneumoniae lgM
|
| | Bordetella pertussis lgG ( )
|
| | Bordetella pertussis lgM ( )
|
| | Mycoplasma tuberculosis ()
|
| | (,)
|
| | -
|
| | Heliobacter pylori lgG
|
| | Helicobacter pylori lgG-
|
| | Helicobacter pylori lgA-
|
| | Salmonella typhi lgG\salmonella typhi lgM
|
| | (. ; )
|
| | Shigella sonnei ( ,,)
|
| | Shigella flexneri ( ,,)
|
| | Yersinia enterocolitic03;09(,
-)
|
| | Yersinia pseudotuberculosis (
, -)
|
| |
|
| | Borrelia lgG ( , )
|
| | Borrelia lgM ( , )
|
| | Brucella (, -
)
|
| | Listeria (, -
)
|
| |
| | Candida albicans lgG
|
| | Candida albicans (m5) lgE
|
| | Aspergilius fumigatus lgG
|
| | Aspergilius fumigatus (m3) lgE
|
| | , ,
| | Toxoplasma gondii lgG ( )
|
| | Toxoplasma gondii lgM ( )
|
| | lgG k Toxoplasma gondii
(Toxoplasma lgG Avidity)
|
| | Toxocara canis lgG ( )
|
| | lgG ( ): lgG, lgG, lgG, lgG
|
| | - (
): lgG, lgG lgE. lgG
, lgG, lgG lgE, lgE
|
| | lgG
|
| | lgE
|
| | lgG
|
| | lgG
|
| | lgE
|
| | lgG
|
| | lgE
|
| |
|
| | lgG
|
| | (P.malarie,
P.falciparum,P.vivax)
|
| |
| | ( ): - , - (D3), -
(CD3+CD4+), - (CD3+CD8+),
(CD4+\CD8+),
-(CD19+),
(NK- CD16\CD56), - (-NK-
CD3+CD16\CD56)
|
| | (, ,
, , )
|
| | ( -
):
|
| |
| |
G (lgG)
|
| | (lgM)
|
| | (lgA)
|
| | E (lgE)
|
| | - (-
: -, -
)
|
| | ( -
)
|
| |
|
| |
|
| | 3
|
| | 4
|
| | 1 -
|
| | 1 -
|
| | ( )
|
| |
|
| | 1β
|
| | 6
|
| | 8
|
| | 10
|
| | -
|
| | ( ):
, (3, 4 , lgA, lgM, lgG, lgE, , -
|
| | - :
, , -
(3, 4 , lgA, lgM, lgG, lgE,
, - )
|
| |
| | ( ):
, , α Υ
|
| |
(
)
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
( )
|
| |
|
| |
|
| | ()
|
| |
|
| |
|
| |
( )
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| | -
|
| |
|
| |
| |
( , , .)
|
| | :
dsDNA,RNP\Sm,SS-A(Ro),SS-B(La),Scl-70,Jo-1,
ENP-B, AMA M2
|
| | 2- lgG(.)
|
| |
(.)
|
| | (; -
|
| | ): :
SS-A52,SS-A60,SS-B,RNP,Sm,,Jo-1,Scl-70,
|
| | (lgG)
|
| |
( ):
(ANA -), 2- lgG(dsDNA),
|
| | -
(, ):
-3(anti-PR3), (anti-MPO), anti-GBM
|
| | -
( ):
: -3 (anti-PR3),
(anti-MPO),
BPI,, G,
,
|
| | ( -
, ): 2, Jo-1,PL-7,
PL-12,PM-Scl-100,Mi-2,Ku(p70\80),SRP,Rip-P
|
| | 1q
|
| |
( ):
( : anti-PR3, anti-MPO, anti-BPI, ,
G, , )
|
| |
( ):
, (-
: anti-PR3, anti-MPO, antiGBM)
|
| |
|
| |
|
| |
(anti-)
|
| | -
(anti-MCV)
|
| |
( ):
, (anti-CCP).
(anti-MCV)
|
| | -
( ):
, HLA-B27 ()
|
| |
|
| | lgG
(.): ,
, -
,
|
| | lgM (.): , ,
,
|
| |
|
| | lgG (.)
|
| | lgM (.)
|
| | 2- lgG (.)
|
| | 2- lgM(.)
|
| |
( ):
lgG, lgM, (ANA- )
|
| |
|
| | \-
+
( , )
|
| |
( )
|
| |
|
| |
( , -
, , )
( , ):
, ,
, ASSA-AT k
Saccharomyces cerevivae
|
| |
( ):
: -3 (anti-PR3), -
(anti-MPO), I, ,
G, ,
|
| | lgA (lgA ) (.)
|
| | - (
): -
()+
lgA(.)
|
| | - lgG(AAI)+ GAF-3X ( )
|
| | lgG lgA()
|
| |
|
| | \-
+
( , ):
: (-2),
(sp100, gp210),
\
(SLA\LP),
1 (LKM-1),
1 (LC-1), (F-, , )
|
| | - (
)
|
| | (GAD)
|
| | A
|
| | - (-IA2)
|
| | lgG4 (
)
|
| |
|
| | ()
|
| |
|
| |
|
| | ()
|
| | ()
|
| |
(
)
|
| | ( ,
): : 2, Jo-1,PL-7,
PL-12,PM-Scl-100,Mi-2,Ku(p70\80),SRP,Rip-P
|
| | ( )
|
| | (lgG+lgM) ( , ): : GM1, GM2, GM3, GM4, GD1a, GD1b,
GD2,GD3,GT1a,GT1b,GQ1b,
|
| | (lgG) ( , ):
: GM1, GM2, GM3, GM4, GD1a, GD1b,
GD2, GD3, GT1a, GT1b, GQ1b,
|
| | lgG (
, ): :
GM1,GM2,GM3,GM4,GD1a,GD1b,GD2,GD3,GT1a,
GT1b,GQ1b,
|
| | (
, ): :
GM1,GM2,GM3,GM4,GD1a,GD1b,GD2,GD3,GT1a,
GT1b,GQ1b,
|
| |
|
| | (-)
|
| | (-)
|
| |
|
| |
|
| |
|
| |
|
| |
|
| | (.)
|
| |
|
| |
|
| | lgG()
|
| | () -2 ()
|
| | -2 ()
|
| |
( ): ,
+
|
| |
( ):
Yo-1,Hu,Ri,Ma,Amphyphisin +
|
| | ( ): , +
|
| | -
( ): lgG
lgA, ASCA lgG lgA,
+
|
| | -
(
): (); -
(), lgA, lgG
( lgA, lgG), lgA( lgA) +
|
| | -
| | -
|
| | (V)
|
| | (V)
|
| |
(HBV)
|
| | (HCV)
|
| |
(V)
|
| | (HCV)-Roche ()
|
| | (HCV) (-
1,1b,2,3)
|
| | D(HDV)
|
| | G(HGV)
|
| | (V)
|
| | 1,2 (Herpes simplex virus)
|
| | (CMV)
|
| | -(EBV)
|
| | -(VZV)
|
| | 6
(HHV 6)
|
| | 8
(HHV 8)
|
| | (Rubella virus)
|
| | (Parvovirus B19)
|
| | -
|
| | - -
: , ,
1N1, H5N1,
(1,2,3,4 ), (OC43,229F, HKU1,
NL63), , ,,
- ,
; Streptococcus pneumoniae,
Mycoplasma pneumoniae,Chlamydia pneumoniae
|
| |
|
| | - ( , ,
1N1, H5N1, (1,2,
3,4 ), (43,229F, HKU1, NL63)
, , , -
- , )
|
| | (Human Coronavirus
NL63,Human Coronavirus 229E,Human Coronavirus HKU1,Human Coronavirus OC43)
|
| | -
(Respiratory Syncytial Virus)
|
| | (Human adenovirus)
|
| | ( ): Streptococcus
Pneumoniae, Micoplasma pneumoniae, Chlamydia
pneumoniae
|
| | Streptococcus pneumoniae
()
|
| | Streptococcus pyogenes ( )
|
| | Streptococcus agalactiae (-
)
|
| | Chlamydia pneumoniae
|
| | Mycoplasma pneumoniae
|
| | -
|
| | Chlamydia trachomatis
|
| |
|
| | (Treponema
Pallidum)
|
| | -
|
| | Toxoplasma gondii
|
| | Listeria monocitogenes
|
| |
| | (lgE OH)
|
| |
|
| |
|
| | (lgE )
| | -: -
lgE
|
| | : lgE 75
|
| |
(8 : , ,
, , , , , -
|
| | (lgG4)
|
| |
( 24): lgG4 75
|
| |
( 96 ): lgG4 115 -
|
| |
( 192 ): lgG4 203 -
|
| | :
( 24
): lgG4 lgE 75
|
| | (lgE
)
|
| | : ,
, , , , ,
|
| | \-:
, , , ,
, , , Alternaria
alternata
|
| | :
, ,
|
| | : ,
, ,
|
| | :
Aspergillus fumigatus, Penicillin notatum,Mucor racemosus, Malassezia spp., Candida albicans
|
| | : Alternaria
Alternate, Cladosporium herbarum, Fusarium moniliforme
|
| | :
,
, TSST
|
| | ( ):
| | (
lgE ,
)
|
| |
|
| |
|
| |
|
| | : , , ,
|
| | : , , (,
), (,
)
|
| | : , , , (, ). (,
)
|
| | : , .
,
|
| | : , , ,
,
|
| | : ,
, , ,
|
| | : , , , ,
|
| | : , ,
. ,
|
| | : ,
, ,
,
|
| | : ,
, ,
, ()
|
| | : ,
, ,
,
|
| | : , , , ,
|
| | : ,
, (),
, ( )
|
| |
| | : , , ,
,
|
| | , : , , ,
|
| | , : , , ,
|
| | : ,
, , ,
|
| | : , ,
,
|
| | : , , ,
|
| | : , , ,
|
| | : , , , ,
|
| | : , , ,
|
| | : , , ,
|
| | : , , , ,
|
| | : , , , ,
|
| | lgE
| |
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
| | ()
|
| | ()
|
| |
|
| |
|
| |
|
| | ( )
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| | ()
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| | d1 (House dust mite\
Dermatophagoides pteronyssins)
|
| | d2(Dermatophagoides farinae)
|
| | d3(Dermatophagoides microceras)
|
| | d74(Euroglyphus maynei)
|
| | 1
|
| | 2
|
| |
|
| | m2(Cladosporium herbarum)
|
| | m6(Alternaria alternata)
|
| |
|
| | m1(Penicillium notatum)
|
| | , m3
(Aspergillus fumigatus)
|
| |
|
| | m4 (Candida albicans)
|
| | m227(Malassezia spp,)
|
| |
|
| |
|
| | TSST
|
| |
|
| | ,
|
| | ,
|
| | ,
|
| | ,
|
| | ,
|
| | , ,
|
| | , ,
|
| | ,
|
| | ,
|
| | ,
|
| | ,
|
| | ,
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| | ()
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| |
|
| | , ,
|
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© 2015-2024 lektsii.org - -
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