2. , . , . 2Y12 . , ( ).
. , , , CYP2C19 , .
* CYP2C19 - 450 (S- ) 5- 5'- . CYP2C19 .
3 CYP2C19:
1. (), .
2. (), .
3. , .
2.
, ( ) . 2Y12 . CAPRIE (Clopidogrel versus Aspirin in Patients at Risk of Ischemic Events), CURE (Clopidogrel in Unstable angina Recurrent Events), CREDO (Clopidogrel for the Reduction of Events During Observation) .
3. , , . , 5 44% . - [ . () , . , .] 15 , 3 960 , , 25% , , . . , B. Aleil , 75 / 150 / () ( , - ) 33% 12% .
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4. : 1. ; 2. ; 3. ; 4. ; , , . .
5.
, , -450 *, P2Y12. GPIIb/IIIa ** . , . 1- . 2- -450 (CYP2C19, CYP2C9, CYP3A4, CYP3A5), . 3- , , P2Y12, GPIIIa.
* 2-- ( ), - , 85 %
** GPIIb-IIIa Rc , ( Rc). .