.


:




:

































 

 

 

 





-, . - XY ( 1). , . - , . , - .

- . , . (Meyers-Wallenand et al., 1989b). , , . , , . . , .

, . , . . XY . , . , . , . , , , .

(Peter et al., 1993). XY , . . , . . , ; , . , , (Summerfield et al, 1995). , , , , .

XY, - . , -. , , , . . , -. . 50% , 50% . 50% - . , .

, . , , . . , 8 , 10- . , . . -, . -, . , , . . , . , , , , . , () , , . -, . , . , , , , . , , , , . , .

Goodfellow PN, Lovell-Badge R: SRY and sex determination in mammals. Annu Rev Genet 27:71-92, 1993. This article reviews current medical and experimental evidence supporting the pivotal role of Sry in sex determination.

Koopman P, Gubbay J, Vivian N, et al: Male development of chromo-somally female mice transgenic for Sry. Nature (London) 351:117, 1991. This landmark transgenic study demonstrates that Sry is the only genenecessary for testis induction.

Meyers-Wallen VN, Patterson DP. XX sex reversal in the American cocker spaniel dog: Phenotypic expression and inheritance. Hum Genet 80:23, 1988. This article contains the breeding experiments that defined the mode of inheritance of this disorder and describes the range of phenotypic abnormalities.

Meyers-Wallen VN, Patterson DF: Disorders of sexual development in the dog. In: Kirk RW, Bonagura JD, eds: Current Veterinary Therapy X. 1989a, pp 1261-1269. WB Saunders, Philadelphia: This is the first review of this subject in dogs, which is updated by the present article.

Meyers-Wallen VN, Wilson JD, Griffin JE, et al: Testicular fem-inization in a cat. J Am Vet Med Assoc 195:631, 1989b. This is the only report of complete testicular feminization syndrome in the cat.

Meyers-Wallen VN, Donahoe PK, Ueno S, et al: MuUerian inhibiting substance is present in testes of dogs with persistent mullerian duct syndrome. Biol Reprod 41:881, 1989c. These experiments demonstrate that bioactive MIS is produced by dogs affected with inherited PMDS.

Meyers-Wallen VN, Manganaro TF, Kuroda T, et al: The critical period for mullerian duct regression in the dog embryo. Biol Reprod 45:626, 1991. This study defines the gestational ages during which canine mullerian and wolffian development normally occur. Meyers-Wallen VN, Lee MM, Manganaro TF, et al: Mullerian inhibiting substance is present in embryonic testes of dogs with persistent mullerian duct syndrome. Biol Reprod 48:141,1993. This study refines the gestational age at which canine genitalia develop and demonstrates that MIS is produced in embryos affected with PMDS. Meyers-Wallen VN, Palmer VL, Acland GM, et al: Sry-negative XX sex reversal in the American cocker spaniel dog. Mol Reprod Dev 41:300,1995a.

Meyers-Wallen VN, Bowman L, Acland GM, et al: Sry- negative XX sex reversal in the German shorthaired pointer dog. J Hered 86:369,1995b. This study demonstrates that Sry is absent in German shorthaired pointers affected with XX sex reversal. Peter AT, Markwelder, Asem EK: Phenotypic feminization in a genetic male dog caused by nonfunctional androgen receptors. Theriogenology 40:1093,1993. This is the only report of incomplete testicular feminization in the dog.

Shille VM, Olson PN: Dynamic testing in reproductive endocrinology. In: Kirk RW, Bonagura JD, eds: Current Veterinary Therapy X. 1989, pp 1282-1288. WB Saunders Philadelphia: This review describes the protocol for canine and feline gonadotropin-releasing hormone and human chorionic gonadotropin stimulation tests. Summerneld AE, Craz PJD, Dolenga MP, et al: Tissue-specific pharmacology of testosterone and 5-alpha-dihydrotestosterone analogues: Characterization of a novel canine liver androgen-binding protein. Mol Pharmacol 47:1080, 1995. This study indicates that the canine androgen receptor can exhibit different binding affinity preference for DHTrelative to T.

Swain A, Zanaria E, Hacker A, et al: Mouse Daxl expression is consistent with a role in sex determination as well as in adrenal and hypothala-mus function. Nat Genet 12:404, 1996. This study describes embryonic Daxl expression, providing support for a role in ovarian differentiation.

 



-

.


. , . 300 , , ( D. Peterson). , . , , . .





:


: 2018-10-18; !; : 247 |


:

:

, .
==> ...

1702 - | 1588 -


© 2015-2024 lektsii.org - -

: 0.009 .