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Definition and principles of replication




, ,

6.4.3. Қ ң ә ң .

6.4.4. ғ қ ң қ.

6.4.5. қң , ә ү

6.4.6. Қ қ, құ ә

6.4.7. қң ә қ Қ ң өң ң қ қ ң.

* ғ ә ү

6.5. қ ә: ң қң ә, қ ә ; ү ққ, қ, ү ә ү ұқ, , ү ө; қ ұ; ғ ө ә ү, ғ ғ ұ, қ ө.

6.6. Ә:

:

6.6.1. Ққ .Ө., .. қ (ә ғ). : , 2008. .21-41.

6.6.2. .., .. . ., 2003. . 17-40.

6.6.3. . . .. .: , 2006. . 52-53.

6.6.4. Ққ .Ө., ұ Ұ.Ә. қ-қ ң -ққ ө. : , 2012. 112 .

Қ:

6.6.5. .. . : .. -, 2007. .110-122.

6.6.6. .., .. . ., 2003. . 11-16.

6.6.7. . . .. 2- . .: , 2004. .1. . 234-242.

6.6.8. .., .. . . -- , 2002. .106-116.

6.6.9. : . / ., . -, . : . . . . ; . . . . .- ., -, 2010. . 203-205.

6.7. қ:

() құ ғ

6.7.1.1. қ ұқ ұ.

6.7.1.2. қ 3 ұқ 10 ұқ.

6.7.1.3. қ ә ғ ә

 

6.7.2. ә ғ құ ғ:

6.7.2.1. :

-Қ ң (Ққ .Ө., .. қ (ә ғ), 9 , 23 .

- Қ -ң ә ң (Ққ .Ө., .. қ (ә ғ), 11 , 25 .

 

ғ.

Қ ө ұ:

3 .. .... 5 .қ Қ өң ә ғ Қ ң ң құ ң. ң қ қ, қ ң өң.

 

6.7.2.3. Қ қ ң қ .

 

ү Қ
1.  
2. SSB -  
3.  
4. Қ -  
5.  
6. Қ -  
7.  

 

6.7.2.4. ң қ ә ң қ Қ өң ұ ү ә .

6.7.3. қ ұқ:

6.7.3.1. қң ә ү

6.7.3.2. ң Қ ң .

Ү ү ө:

Ққ ғ
Қ ң ү Replication process of doubling of DNA molecule
Replicon unit of replication
Қ-ң ү ң ң қ Қ-ң ққ , , Primer short (oligonucleotide) fragment of RNA, synthesizing before replication and using for initiation of synthesis of daughter chain
- Қ-ң ң ң қ - , DNA-polimerase enzyme, taking part on synthesis of daughter chain of DNA
қ Қ-ң ң Қ ң , Okasaki fragments fragments of daughter chain of DNA, synthesizing on lagging chain of maternal DNA
Қ ә қ ң , hromatin material of chromosomes, consisting mainly from DNA and proteins
ң ұ қ қ, Қ-ң қ қ , , Telomeres repetitive sequence of DNA located on the ends of chromosomes not containing genes  
қ Қ ң ң ұ, қ ә қ , , Telomerase specific enzyme lengthening daughter chain of DNA, are active in malignant tumors and other cells  
қ ң ғ ғ ә ү () - Leading strand strand synthesized continuously and along the direction of replication fork.
(қ) қ ң ғ қ ғ ә ү-ү () Lagging strand strand synthesized discontinuously and against the direction of replication fork.
Қ-ң қ ң әқ ң ү ү - () Semi-conservativeness each original (maternal) DNA chain acts as a template for synthesis of a daughter chain
қ Қ ң ң ң ң ң ү - , Complementarity biosynthesis of daughter DNA chains is based on complementary pairing of adenine with thymine, and guanine with cytosine
Қ ң қ қ-қ ғ - Antiparallelity -synthesis of a daughter DNA strand happens in the direction opposite to the direction of maternal chain
ғ- ң ң 5¢-3¢ғ - 5¢-3¢ Unipolarity synthesis of complementary daughter strands is always in the 5 to 3 direction
Ү Қ ң қ , - , Discontinuousness replication starts simultaneously at several points of a DNA molecule, which are later joined in a continuous chain
ұқ қ қң -қ ғң ү Қ-Қ- Қ--Қ- Қ қ- -- --- - Generaltransfer of hereditary information occurs in cells of all living organisms DNA-DNA replication DNA-mRNA transcription RNA-protein translation
ұқ қ қң қғ ү Қ-Қ- Қ--Қ- Қ қ- -- -- - Specializedtransfer of hereditary information occurs in cells infected with a virus RNA-RNA replication RNA-DNA transcription DNA-protein translation

 

Құғ: қ ..

4 -ә қ





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