:
- NH3
N-
N2
-
--
--
---
. , ( ). :
NH3
. , , *2, , *2, - , -.
-
COOH
|
HOOC CH2 CH2 CH COOH CH2
| - CO2 |
NH2 CH2
|
CH2 NH2
COOH COOH COOH
. | HSKoA | |
CH2 CH2 CH2 ()
| | |
CH2 CH2 CH2
| | |
H C = O O = C SKoA COOH
, ( 25% ), :
HOOC CH2 HOOC COOH COOH
| | | |
CH2 - (CH2) CH2 CH2
| | | |
CH NH2 CH2 CH CH2
| | | | *2
COOH NH2 O = C H COOH
COOH
|
CH2
|
CH2
|
CH2OH
. . ( , , 6, .
, . . , ( ). .
|
|
.
:
COOH COOH COOH COOH
| | | |
CH2 (CH2) CH2 (CH2)
| + | | + |
C = O CH NH2 CH NH2 C = O
| | | |
COOH COOH COOH COOH
:
1. ( )
2.
3.
4. - -
COOH CH3 CH COOH
| | COOH
CH2 NH2 |
| CH2
CH NH2 - CO2 |
| CH2 NH2
COOH -
- , HS-KoA. , .
5.
, .
6. . , :
O O HOOC C = O
|| || R |
R C COOH + HOOC CH CH2 C | + CH2
| | CH NH2 |
NH2 NH2 | C = O
COOH |
NH2
-
NH2 COOH
| |
C = O CH2
| + HOH | + NH3
CH2 C = O
| - |
C = O COOH
|
COOH
-
, - .
7. ( ).
.
3 :
1.
N N
CH2 CH COOH CH2 CH2 NH2
| - CO2
NH NH2 NH
O
N + HOH N //
CH2 CH2 NH2 NH3 + CH2 C + H2O2
NH NH \
H
2.
N
CH2 CH COOH + H2N CH2 CH2 COOH
NH | - -
NH2
N N
CH2 CH COOH CH2 CH COOH
| |
NH NH N NH
| | |
H2N CH2 CH2 C = O CH3 CO
|
(CH2)2 NH2 :
3.
N N
CH2 CH COOH CH = CH COOH
NH | - NH3 NH
NH2
.
:
O
*2 //
HOOC CH2 CH2 CH COOH HOOC CH2 (CH2) C
- - \
H
COOH O = COOH
- NH NH
5-
COOH COOH
O = COOH | | GSH
NH CH2 CH2 CH NH2
5- +