, ( ) . , (), , (). [22].
1. ();
2. () (, , );
3. ;
4. ;
5. ;
6. ;
7. ;
8. , .
. , , , .
() , . :
HNOEL , (NOEL no-observed-effect level, .. , );
HNOAEL , (NOAEL no-observed-adverse-effect level, .. , );
HLOEL , (LOEL lowest-observed-effect level, .. , );
HLOAEL , (LOAEL lowest-observed-adverse-effect level, .. , ).
, . , , ; , /().
HD,T ( HD,T - HNOEL-A, HNOAEL-A, HLOEL-A, HLOAEL-A) :
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HD,T = cv/M, (5.41)
c ; v , ; .
, . . , . : F 1, F 2 F 3, :
HD,A = HD,T /(F 1 F 2 F 3), (5.42)
HD,A .
F 1 , .. . , F 1 , 10. , F 1=1.
F 2 , . 1 10; F 2=1 ( ).
F 3 , . 10 100. HNOEL HNOAEL , , F 3=10. HLOEL HLOAEL F 3=100.
, F 1, F 2 F 3 .
5.19. , HNOAEL 1 /. , . HNOAEL , ?
. F 1 = 10, . F 2=1, , . F 3=10, HNOAEL , HNOAEL .
, (5.42):
HNOAEL-A = HNOAEL /(10110) = 0,01 /.
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