P2Y12 . P2Y12 Gi-, , -3-, Akt/ , Src-, G- . P2Y12 , . P2Y12 , .
13.
5 P2Y12 98 . 4 , H1 H2 0,86 0,14, . H2 - , 1. 34 P2Y12 , .
14.
, - . , . R (, ). , , P-450 CYP3A , , . - ( - ). : -293G CYP3A4, G6986A CYP3A5, C18T G36T P2Y12, Leu33Pro GPIIIa, C-154T T13254C GPVI,C807T GPIa.
15.
G36T P2Y12, C-154T T13254C GPVI, C807T GPIa T18 P2Y12, , . Leu33Pro GPIIIa, . 293G CYP3A4, .
16.
60 (R; , ) 75 / (; , ) P-450 CYP29, CYP2C19 P2Y12 GPIIIa. 75 / , 5 2 . . 2 80% , 20% . (7 ) 12 , - - . , .
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17.
. , , CYP2C19 . . () , , .