. - ABCB1. , . 3435 ABCB1 (). , (n=2 208), . ( ) - , ( , ) (15,5% 10,7%).
7.
-450 CYP2C19 . CYP2C19 2--. 20 CYP2C19 ( ). CYP2C19*2 CYP2C19*3. (Cmax) AUC 30-50% 300 600 75 . TRITON-TIMI 38 (CYP2C19*2, CYP2C19*3) CYP2C19 ( 30% ) 32,4% (p<0,001). , 9% , (p<0,001).
8.
, TRITON-TIMI 38, 53% - , (12,1% vs 8,0%; 1,53), 3 (2,6% vs 0,8%; 3,09).
9.
CYP2C19*2 (>14%) () . 797 , . 1 . (5 /) 600 75 . 552 (69,3%) CYP2C19 (*1/*1), 245 (30,7%) , , *2. . *2- (p<0,001) >14% (62,4% vs 43,4%), (41,3% vs 22,5%).
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10.
30 CYP2C9. CYP2C9*2 CYP2C9*3 CYP2C9. CYP2C9*2 CYP2C9*3 . CYP2C9 . CYP2C9*2 CYP2C9*3 Cmax 47% (p=0,006), AUC 40% (p=0,043) 37% 4 300 (p=0,046) .
11.
CYP3A4 , CYP2C19 CYP2C9, . CYP3A4, 25 . , CYP3A4 - (20 /) .