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The mechanism of hormonal action




 

1. Indicatethe right answer

Adrenaline activates membrane enzymes

A. Cholinesterase

B. Phosphatase

C. Catalase

D. Glycogensintetase

E. Adenylate cyclase

 

2. Indicatetheright answer

Adenylate cyclase activates

A. Glucagon

B. Melanotropin

C. Cortisone

D. Progesterone

E. Aldosterone

 

3. Indicatethe right answer

Adenylate cyclase complex is a

A. Set of cytoplasmic receptors

B. Association of three components: the receptor, and a coupling mechanism catalytic

C. Cytoplasmic multienzyme complex

 

4. Indicatethe right answer

Cyclic nucleotides

A. Inhibit phosphodiesterase

B. Activates phosphodiesterase

C. Regulate hormone secretion

D. Activate protein kinase capable of phosphorylating proteins

E. Regulate the nerve impulses

F. Inhibit protein kinase

 

5. Indicatethe right answer

Insulin binds to the target cells

A. Nuclear receptor glycoprotein

B. Glycoprotein cytoplasmic receptors

C. With a mitochondrial glycoprotein receptor

D. Glycoprotein with a receptor on the plasma membrane

 

6. Indicatethe right answer

Second messenger hormone in the cells are all of the below mentioned except

A. c-GMP

B. Peptides

C. Calcium ions

D. c-AMP

E. Sodium ions

 

7. Indicatethe right answer

Membrane type of reaction is characteristic of all hormones, except

A. atecholamine

B. Tyrosine derivatives

C. Tryptophan derivatives

D. Hormones steroid nature

E. Protein-peptide

 

8. Indicatethe right answer

Intracellular receptor type characteristic of the hormone is

A. Iodothyronines

B. atecholamine

C. Steroid hormones

D. Glucocorticoids

E. Mineralcortikoid

F. Sex

G. Tryptophan derivatives

 

9. Indicatethe several correct answers

Time stages of hormonal effect in a target cell

A. Early

B. Short

C. Immediate

D. Remote

E. Initial

F. Older

10. Indicate theseveral correct answers

Mediators involved in the implementation ofhormonal effects are all the below mentioned except

A. -GMP

B. Calcium ions

C. Magnesium ions

D. Of potassium ions

E. Peptides

 

11. Indicate the right answer

Target cells catecholamines are all the below mentioned except

A. Liver

B. Kidney

C. Adipose tissue

D. Muscle

 

12. Indicate the right answer

Effects of catecholamines exert via a transmitter

 

A. Calcium ions

B. Phosphatase

C. Adenylate cyclase

D. Phosphodiesterase

E. Protease

13. Indicate the several correct answers

state hormones, characteristic of membrane cytoreception

A. Estrone

B. Estradiol

C. Insulin

D. Testosterone

E. Adrenaline

F. Cortisone

G. Thyroxine

 

14. Indicate the several correct answers

Hormones, which act by intracellular reception

A. Adrenaline

B. Glucagon

C. Testosterone

D. Insulin

E. Calcitonin

F. Thyroxine

 

15. Indicate the several correct answers

Insulin increases membrane permeability to

A. Glucose

B. Potassium ions

C. Sodium

D. Amino acids

E. Phosphate

F. Calcium ions

 

16. Indicate the several correct answers

membrane permeability of insulin independence are only cells of

A. Erythrocytes

B. Heart

C. Muscle

D. Liver

E. Brain

F. Kidney

 

17. Indicate the several correct answers

Hormones that bind to receptors located in the cytoplasmic membrane of the cell are

A. Glucagon

B. Androsterone

C. Adrenaline

D. STG

E. Progesterone

 

18. Indicate the right answer

The hormone binds to the receptor, localized in the cytoplasm of cells is called

A. Insulin

B. Melanoliberin

C. Estradiol

D. Calcitonin

E. Adrenaline

 

19. Indicate the right answer

The hormone binds to the receptor, localized in the cytoplasm of cells is called

A. Parathyroid hormone

B. Melanostatin

C. Glucagon

D. Insulin

E. Cortisol

 

20. Indicateseveral correct answers

Insulin deficiency results in the development of

A. Diabetes

B. Steroid diabetes

C. Hypoglycemic coma

D. Hyperlycemic coma

E. Increase in the permeability of cell membranes to glucose

 

21. Indicateseveral correct answers

hormones, which increase the concentration of glucose in the blood are

A. Mineralocorticoids

B. Glucocorticoids

C. PTH

D. Glucagon

E. Epinephrine

F. Insulin

 

22. Indicateseveral correct answers

Epinephrine activates

A. Glycogenolysis

B. Lipogenesis

C. Lipolysis

D. Glycolysis

E. Pentose phosphate pathway

 

23. Indicatethe right answer

Hormone which reduces the concentration of glucose in the blood

A. Glucocorticoids

B. Insulin

C. Epinephrine

D. Glucagon

E. Thyroxine

 

24. Indicateseveral correct answers

Insulin deficiency leading to hyperglycemia results in

A. The permeability of cell membranes reduction

B. The permeability of cell membranesreduction

C. Acceleration of glycolysis

D. Braking of glycogenesis

E. Inhibition of the Krebs cycle

F. Inhibition of gluconeogenesis

 

25. Indicatethe right answer

Insulin preparations is not indicated for oral use, because of

A. Inactivated hydrochloric acid

B. Excretion in the feces

C. Binding with bile acids

D. Exposure to proteolysis in the stomach and intestine

E. All the answers are correct

 

26. Indicateseveral correct answers

Diabetes is happening in case of

A. Reduction in the rate of glycogenolysis

B. Increased activity of acetyl-CoA carboxylase

C. Decreased activity of acetyl-CoA carboxylase

D. An increase in the synthesis of acetoacetate

E. Reduting in the rate of gluconeogenesis

F. Accelerated glycogen synthesis

 

27. Indicatethe right answer

Insulin which isundercontrolof enzyme glycogen synthesis

A. Glucose 6-phosphatase

B. Glycogen

C. Glycogen phosphorylase

D. Phosphoglucomutase

 

28. Indicateseveral correct answers

Glycogen is activated by

A. Phosphorylation

B. Dephosphorylation

C. Fructose-1,6-diphosphate

D. Glucose 6-phosphate

E. Glycogen

 

29. Indicatethe right answer

Hypoglycemia can occur when there is no

A. Hypothyroidism

B. Hyperfunctions of b-cells of islets of Langerhans of the pancreas

C. Hyperparathyroidism

D. Fasting

E. Hypofunction of b-cells of islets of Langerhans of the pancreas

 

30. Indicateseveral correct answers

Hormonesensitive lipase in adipocyte hormones is activated by

A. Epinephrine

B. Glucagon

C. Thyroxine

D. Cortisone

E. Insulin

31. Indicateseveral correct answers

Hormonesensitivelipase in adipocytesdo not activate such hormones as

A. Thyroxine

B. Epinephrine

C. Cortisone

D. Glucagon

E. Insulin

 

32. Indicateseveral correct answers

An activator of regulatory enzymes of fatty acids acetyl Coa carboxylase is

A. Malate

B. Insulin

C. Glyconate

D. Citrate

E. Oxaloacetate

 

33. I ndicatethe right answer

A hormone, which causes a decrease in blood glucose

A. Glucagon

B. Somatotropin

C. Insulin

D. Cortisol

E. Epinephrine

 

34. Indicatethe right answer

Insulin regulates the process, except

A. Increases the activity of enzymes of glycolysis

B. Increases the permeability of membranes for glucose and amino acids

C. Accelerates the catabolism of proteins

D. Accelerates the utilization of glucose by cells

E. Increases the activity of enzymes pentose phosphate pathway

 

35. Indicatethe right answer

Glucagon regulates processes

A. Enhances glycogenolysis

B. Accelerates the catabolism of proteins

C. Increases the permeability of cell membranes

D. Enhances the secretion of hormones

E. Accelerates the utilization of glucose by cells

 

36. Indicatethe right answer

A hormone, which accelerates lipogenesis

A. Epinephrine

B. Thyroxine

C. Insulin

D. Glucagon

E. Calcitonin

 

37. Indicatethe right answer

Lipolysis further accelerates such hormones as

A. ACTH

B. Glucagon

C. Insulin

D. Somatotropin

E. Epinephrine

 

38. Indicatethe right answer

A hormone, which accelerates glycolysis

A. Insulin

B. GH

C. Epinephrine

D. ACTH

E. Glucagon

 

39. Indicatethe several correct answers

A hormones, whichaccelerate the process of glycogenolysis

A. ACTH

B. Epinephrine

C. Glucagon

D. Insulin

E. Thyroxine

F. Glucocorticoids

 

40. Indicatethe right answer

Hyperglycemic effect is characteristic of allthe hormones, except

A. Glucocorticoids

B. ACTH

C. Epinephrine

D. Insulin

E. Glucagon

 

41. Indicatethe right answer

Hypoglycemic action is characteristic of the following hormone

A. Parathyroid hormone

B. Insulin

C. Glucocorticoids

D. Glucagon

E. Epinephrine

 

42. Indicateseveral correct answers

Hypoglycemia leads to the following conditins

A. Weakening of glucagon

B. Decrease of insulin secretion

C. Enhancing of insulin secretion

D. Increased secretion of glucagon

E. The weakening of ACTH secretion

F. The weakening of growth hormone secretion

 

43. Indicateseveral correct answers

Hyperglycemic conditions leads to

A. Weakeningof insulin secretion

B. Weakening of glucagon

C. Increased secretion of glucagon

D. Increased secretion of ACTH

E. Increased secretion of growth hormone

F. Enhancing of insulin secretion

 

44. Indicatethe right answer

A hormone, which slows down the process of gluconeogenesis

A. Insulin

B. Epinephrine

C. Glucagon

D. Glucocorticoids

E. ACTH

 

45. Indicateseveral correct answers

Hormones, whichaccelerate the process of gluconeogenesis

A. Epinephrine

B. Glucocorticoids

C. Glucagon

D. ACTH

E. STG

F. Insulin

46. Indicatethe right answer

Glucagon in adipose tissue activates

A. Acyl-CoA dehydrogenase

B. Pyruvate

C. Lipoprotein lipase

D. Hormonesensitive TAG-lipase

E. Glucose-6-phosphate dehydrogenase

 

47. Indicateseveral correct answers

CAMP is

A. The membrane receptor for a protein-peptide hormones

B. Phosphodiesterasesubstrate

C. Protein activator

D. The precursor of ATP

A mediator, causing changes in intracellular metabolism

 

48. Indicatethe right answer

All the statements about hormones are true, except

A. All hormones are synthesized in the anterior pituitary

B. Under the influence of hormones the enzyme activitychanges

C. The effects of hormones are manifested throughinteraction receptor

D. Hormones induce synthesis of enzymes in target cells

E. The synthesis and secretion of hormones is regulated by a feedback mechanism

 





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