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Metabolism of ketone bodies. Cholesterol




1. Indicate the right answer

Metabolite of ketone bodiesoxiditation resulting from the following reaction

CH3-CHOH-CH2-COOH + NAD+

A. acetoacetic acid

B. acetoacetyl-CoA

C. acetyl-CoA

D. β-hydroxy-β-methylglutaryl-CoA

E. β-hydroxy-β-glutaryl-CoA

 

2. Indicate the right answer

Metabolite of ketone bodies oxiditation resulting from the following reaction

CH3-CO-CH2-COOH+ATP+HS-CoA

A. acetoacetic acid.

B. β-hydroxy-β-methylglutaryl-CoA

C. acetyl-CoA

D. β-hydroxy-β-glutaryl-CoA

E. acetoacetyl-CoA

 

3. Indicate the right answer

Metabolite of ketone bodies oxiditation resulting from the following reaction

CH3-CO-CH2-COOH+ HOOC-CH2-CH2-CO-S-CA

A. acetoacetic acid

B. β-hydroxy-β-methylglutaryl-CoA

C. acetyl-CoA

D. β-hydroxy-β-glutaryl-CoA

E. acetoacetyl-CoA

 

4. Indicate the right answer

Metabolite of ketone bodies oxiditation resulting from the following reaction

CH3-CO-CH2-CO-S-COA+HS-CoA

A. acetoacetic acid

B. β-hydroxy-β-methylglutaryl-CoA

C. acetyl-CoA

D. β-hydroxy-β-glutaryl-CoA

E. acetoacetyl-CoA

 

5. Compare the names of the metabolites of ketone bodiesoxiditationto their formulas

CH3-CO-S-CoA

A. β-hydroxy-β-methylglutaryl-CoA

B. β-hydroxy-β-glutaryl-CoA

C. acetoacetyl-CoA

D. acetyl-CoA

E. β-hydroxybutyrate

 

6. Compare the names of the metabolites of ketone bodies oxiditation to their formulas

CH3-CHOH-CH2-COOH

A. β-hydroxy-β-methylglutaryl-CoA

B. β-hydroxy-β-glutaryl-CoA

C. acetoacetyl-CoA

D. acetyl-CoA

E. β-hydroxybutyrate

 

7. Compare the names of the metabolites of ketone bodies oxiditation to their formulas

CH3-CO-CH2-COOH

A. acetoacetyl-CoA

B. acetyl-CoA

C. β-hydroxybutyrate

D. β-hydroxy-β-methylglutaryl-CoA

E. acetoacetic acid

 

8. Compare the names of the metabolites of ketone bodies oxiditation to their formulas

CH3-CO-CH2-CO-S-CoA

A. acetoacetyl-CoA

B. acetyl-CoA

C. β-hydroxybutyrate

D. β-hydroxy-β-methylglutaryl-CoA

E. acetoacetic acid

 

 

9. Match the following

Compare the names of the metabolites of ketone bodiesoxidation to their formulas

1. CH3-CO-CH2-CO-S-CoA A. β-hydroxy-β-methylglutaryl-CoA

2. CH3-CO-S-CoA B. acetyl-CoA

C. β-hydroxybutyrate

D.acetoacetyl-CoA

 

10. Match the following

Compare the names of the metabolites of ketone bodies oxidation to their formulas

1. CH3-CO-CH2-COOH A. β-hydroxy-β-methylglutaryl-CoA

2. CH3-CHOH-CH2-COOH B. acetyl-CoA

C. β-hydroxybutyrate

D. acetoacetyl-CoA

E. acetoacetic acid

 

11. Match the following

Compare the names of the metabolites of ketone bodies oxidation to their formulas

1. CH3-CO-CH2-CO-S-CoA A. β-hydroxy-β-methylglutaryl-CoA

2. CH3-CO-CH2-COOH B. acetyl-CoA

C. β-hydroxybutyrate

D. acetoacetyl-CoA

E. acetoacetic acid

 

12. Indicate the correct answer

The enzymewhich catalyzes the oxidation of ketone bodies

CH3-CO-CH2-COOH+ATP+HS-CoA

A. acetoacetyl-CoA thiolase

B. β-hydroxysteroiddehydrogenase

C. succinyl-CoA-acetoacetate-transferase

D. HMG-CoA lyase

E. acyl-CoA synthatase

 

13. Indicate the correct answer

The enzyme which catalyzes the oxidation of ketone bodies

CH3-CO-CH2-COOH+HOOC-CH2-CH2-CO-S-CoA

A. acetoacetyl-CoA thiolase

B. β-hydroxysteroiddehydrogenase

C. succinyl-CoA-acetoacetate-transferase

D. HMG-CoA lyase

E. acyl-CoA synthatase

 

14. Indicate the correct answer

The enzyme which catalyzes the oxidation of ketone bodies

CH3-CO-CH2-CO-S-CoA+HS-CoA

A. acetoacetyl-CoA thiolase

B. β-hydroxysteroiddehydrogenase

C. succinyl-CoA-acetoacetate-transferase

D. HMG-CoA lyase

E. acyl-CoA synthetase

 

15. Arrange in the correct sequence

Metabolites of ketone bodiesoxidation

A. CAC

B. acetoacetyl-CA

C. acetyl-CA

D. β-hydroxybutyrate

E. acetoacetic acid

 

16. Arrange in the correct sequence

Metabolites of ketone bodies oxidation

A. CAC

B. CH3-CO-CH2-CO-S-CoA

C. CH3-CO-S-CoA

D. CH3-CHOH-CH2-COOH

E. CH3-CO-CH2-COOH

 

17. Select the desired object in the picture

Indicate the ATP-dependent reaction in the process of ketone bodiesofoxidation

 

CH3-CHOH-CH2-COOH

1 β-hydroxybutyrate

CH3-CO-CH2-CO-S- CoA

2 acetoacetyl-CA

 

CH3-CO-S-CoA

 

3 acetyl - CoA

CAC

 

18. Select the desired object in the picture

Indicate the reaction catalyzed by acetoacetate transferase in the process of ketone bodiesoxidation

CH3-CHOH-CH2-COOH

1 β-hydroxybutyrate

 

CH3-CO-CH2-CO-S- CoA

2 acetoacetyl-COA

 

CH3-CO-S-CoA

3 acetyl - CoA

 

CAC

19. Select the desired object in the picture

Indicate the reaction of acetoacetic acid formation in the process of ketone bodies oxiditation

CH3-CHOH-CH2-COOH

CH3-CO-CH2-CO-COOH

CH3-CO-CH2-CO-S-CoA

CH3-CO-S-CoA

AC

20. Select the desired object in the picture

Indicate the reaction of acetyl-CoAof formation in the process of ketone bodies oxiditation

CH3-CHOH-CH2-COOH

CH3-CO-CH2-CO-COOH

CH3-CO-CH2-CO-S-CoA

CH3-CO-S-CoA

CAC

 

21. Indicate the right answer

Metabolite of ketone bodiesynthesis resulting from the following reaction

CH3-CO-S-CoA+CH3-CO-S-CoA

A. β-hydroxy-β-glutaryl-CA

B. acetoacetyl-CA

C. acetyl-CA

D. mevalonic acid

E. β-hydroxy-β-methylglutaryl-CA

 

22. Indicate the right answer

Metabolite of ketone bodie synthesis resulting from the following reaction

CH3-CO-CH2-CO-S-CoA +NADPHH+

A. β-hydroxy-β-glutaryl-CA

B. acetoacetyl-CA

C. acetyl-CA

D. mevalonic acid

E. β-hydroxy-β-methylglutaryl-CA

D. β-hydroxy-β-methylglutaryl-CoA

 

23. Indicate the right answer

Metabolite of ketone bodie synthesis resulting from the following reaction

CH3-CO-S-CoA + CH3-CO-S-CoA

A. CH3-CHOH-CH2-COOH

B. HOOC-CH2-C(OH)-CH2-CO-S-CoA

C. CH3-CO-CH2-CO-S-CoA

D. CH2OH-CHOH-CH2OH

E. CH3-CO-S-CoA

24. Indicate the right answer

Metabolite of ketone bodie synthesis s resulting from the following reaction

CH3-CO-CH2-COOH + NADPHH+

A. CH3-CHOH-CH2-COOH

B. HOOC-CH2-C(OH)-CH2-CO-S-CoA

C. CH3-CO-CH2-CO-S-CoA

D. CH2OH-CHOH-CH2OH

E. CH3-CO-S-CoA

 

25. Indicate the right answer

Metabolite of ketone bodie synthesis the formula of which is shown in the picture

CH3-CO-S-CoA

A. mevalonic acid

B. acetoacetyl-CoA

C. acetyl-CoA

D. β-hydroxy-β-methylglutaryl-CoA

E. β-hydroxy-β-lglutaryl-CoA

 

26. Indicate the right answer

Metabolite of ketone bodie synthesis the formula of which is shown in the picture

CH3-CO-CH2-CO-S-CoA

A. mevalonic acid

B. acetoacetyl-CoA

C. acetyl-CoA

D. β-hydroxy-β-methylglutaryl-CoA

E. β-hydroxy-β-lglutaryl-CoA

 

27. Indicate the right answer

Metabolite of ketone bodie synthesis the formula of which is shown in the picture

CH3-CHOH-CH2-COOH

A. β-hydroxybutyrate

B. acetoacetyl-CoA

C. acetyl-CoA

D. β-hydroxy-β-methylglutaryl-CoA

E. β-hydroxy-β-glutaryl-CoA

 

27. Match the following

Compare the names of the metabolites of ketone bodies synthesis to their formulas

1. CH3-CO-S-CoA A. β-hydroxybutyrate

2. CH3-CO-CH2-CO-S-CoA B. acetoacetyl-CoA

C. acetyl-CoA

D. β-hydroxy-β-methylglutaryl-CoA

E. β-hydroxy-β-glutaryl-CoA

 

28. Match the following

Compare the names of the metabolites of ketone bodies synthesis to their formulas

1. CH3-CHOH-CH2-COOH A. β-hydroxybutyrate

2. CH3-CO-CH2-CO-S-COA B. acetoacetyl-CoA

C. acetyl-CoA

D. β-hydroxy-β-methylglutaryl-CoA

E. β-hydroxy-β-glutaryl-CoA

 

29. Indicate the right answer

The enzyme catalyzing the given reactionin the process of ketone bodiessynthesis

CH3-CO-S-CoA + CH3-CO-S-CoA

A. HMG-CoA lyase

B. acetyl-CoA-acetyltransferase

C. β-hydroxysteroiddehydrogenase

D. HMG-CoA synthase

E. diglyceride-acyltransferase

 

30. Indicate the right answer

The enzyme catalyzing the given reaction in the process of ketone bodies synthesis

CH3-CO-CH2-CO-S-CoA + CH3-CO-S-CoA

A. HMG-CoA lyase

B. acetyl-CoA-acetyltransferase

C. β-hydroxysteroiddehydrogenase

D. HMG-CoA synthase

E. diglyceride-acyltransferase

 

31. Indicate the right answer

The enzyme catalyzing the given reaction in the process of ketone bodies synthesis

CH3-CO-CH2-CO-S-COA+ NADPHH+

A. HMG-CoA lyase

B. acetyl-CoA-acetyltransferase

C. β-hydroxysteroiddehydrogenase

D. HMG-CoA synthase

E. diglyceride-acyltransferase

 

32. Arrange in the correct sequence the metabolites of ketone bodiessynthesis

A. β-hydroxybutyrate

B. acetoacetyl-CoA

C. acetyl-CoA

D. β-hydroxy-β-methylglutaryl-CoA

 

33. Select the desired object in the picture

The reaction catalyzed by acetyl-CoA acetyltransferase in the process of ketone bodiessynthesis

34. Select the desired object in the picture

The reaction catalyzed by HMG-CoA lyase in the process of ketone bodies synthesis

 

35. Select the desired object in the picture

The reaction catalyzed by β-hydroxybutyrate dehydrogenase in the process of ketone bodiessynthesis

36. Select the desired object in the picture

The reaction of β-hydroxybutyrate dehydrogenasedegradationin the process of ketone bodiessynthesis

37. Indicate the right answer

Metabolite of cholesterol synthesis resulting from the following reaction

CH3-CO-S-CoA+CH3-CO-S-CoA

A. mevalonic acid

B. acetoacetyl-CoA

C. acetyl-CoA

D. β-hydroxy-β-methylglutaryl-CoA

E. β-hydroxy-β-lglutaryl-CoA

 

38. Indicate the right answer

Metabolite of cholesterol synthesis resulting from the following reaction

CH3-CO-CH2-CO-S-CoA + CH3-CO-S-CoA

A. mevalonic acid

B. acetoacetyl-CoA

C. acetyl-CoA

D. β-hydroxy-β-methylglutaryl-CoA

E. β-hydroxy-β-lglutaryl-CoA

 

39. Indicate the right answer

Metabolite of cholesterol synthesis resulting from the following reaction

CH3-CO-S-CoA + CH3-CO-S-CoA

A. mevalonic acid

B. acetoacetyl-CoA

C. acetyl-CoA

D. β-hydroxy-β-methylglutaryl-CoA

E. β-hydroxy-β-lglutaryl-CoA

 

40. Metabolite of cholesterol synthesis, the formula of which is shown in the picture

CH3-CO-S-CoA

A. mevalonic acid

B. acetoacetyl-CoA

C. acetyl-CoA

D. β-hydroxy-β-methylglutaryl-CoA

E. β-hydroxy-β-lglutaryl-CoA

 

41. Metabolite of cholesterol synthesis, the formula of which is shown in the picture

CH3-CO-CH2-CO-S-CoA

A. mevalonic acid

B. acetoacetyl-CoA

C. acetyl-CoA

D. β-hydroxy-β-methylglutaryl-CoA

E. β-hydroxy-β-lglutaryl-CoA

 

42. Match the following

Compare the names of the metabolites of cholesterol synthesis to their formulas

1. CH3-CO-S-CoA

2. CH3-CO-CH2-CO-S-CoA A. mevalonic acid

B. acetoacetyl-CoA

C. acetyl-CoA

D. β-hydroxy-β-methylglutaryl-CoA

E. β-hydroxy-β-lglutaryl-CoA

 

43. Indicate the right answer

The enzyme catalyzing the given reaction of cholesterol synthesis

CH3-CO-S-CoA + CH3-CO-S-CoA

A. HMG-CoA synthase

B. HMG-CoA reductase

C. diglyceride-acyltransferase

D. thiolase

E. phosphatidycholine

 

44. Indicate the right answer

The enzyme catalyzing the given reaction of cholesterol synthesis

CH3-CO-CH2-CO-S-CoA + CH3-CO-S-CoA

A. HMG-CoA synthase

B. HMG-CoA reductase

C. diglyceride-acyltransferase

D. thiolase

E. phosphatidycholine

 

 

45. Arrange in the correct sequence the metabolites of cholesterol synthesis

A. cholesterol

B. acetoacetyl-CoA

C. acetyl-CoA

D. β-hydroxy-β-methylglutaryl-CoA

E. mevalonic acid

F. squalene

G. lanosterol

 

46. Select the desired object in the picture
NAD+ dependent response of cholesterol synthesis

Acetyl - CoA

1

 

Acetoacetyl - CoA

2

 

HMG - CoA

3

 

Mevalonate

 

47. Select the desired object in the picture
The reaction catalyzed by HMG-CoA synthase in cholesterol synthesis

Acetyl - CoA

1

 

 

Acetoacetyl - CoA

2

 

 

HMG - CoA

3

 

 

Mevalonate

 

48. Determineand specify the enzyme, which activity is inhibited by cholesterol

A. acetyl CoA- transferase

B. acetyl CoA- decarboxylate

C. oxidometylglutaryl CoA-reductase

D. acetyl Coa-acetyltransferase

 

49. Indicate the right answer

All the metabolites formed during the synthesis of cholesterol and ketone bodies

A. mevalonic acid

B. acetoacetyl -CoA

C. acetoacetic acid

D. β-hydroxy-β-methylglutaryl-CoA

 

50. Cholesterol in the cells of the adrenal cortex is used for the biosynthesis of.

A. Corticosteroids

B. Bile acids

C. Vitamin D3

D. sex hormones

E. insulin

 

51. Cholesterol in the cells of sex hormones is used for the biosynthesis of

A. Corticosteroids

B. Bile acids

C. Vitamin D3

D. sex hormones

E. insulin

 

52. Cholesterol in the liver cells is used for the biosynthesis of

A. Corticosteroids

B. Bile acids

C. Vitamin D3

D. sex hormones

E. insulin

 

53. Cholesterol in the skin cells is used for the biosynthesis of..

A. Corticosteroids

B. Bile acids

C. Vitamin D3

D. sex hormones

E. insulin

 

54. Match the followingwith the main transport form

Lipids Transport form

1. triacylglycerol formed in

the enterocytes A. CM

2. triacylglycerol formed in B. LDL

the hepatocytes C. VLDL

D. HLD

E. CE

 

55. Match the following lipids with the main form of transport

Lipids The main form of transport

1. triacylglycerol formed in A. LDL

the hepatocytes B. CM

2. cholesterol C. VLDL

3. triacylglycerol formed in D. HLD

the enterocytes

 

56. Match the following

Transport form of lipids synthesis

1. LDL A. liver

2. CM B. blood

3. VLDL C. intestinal mucosa

4. HLD D. erythrocytes

 

57. Match the following

Cholesterol transport Transport form

1. in tissue A. LDL

2. from tissue B. CM

C. VLDL

D. HLD

58. Insert theright answer (write it down)

Two moles of acetyl Co A are condensed with the formation of (......). This product coudenses with another molecule of acetyl Co A, to form (.......), that is broken down into acetyl Co A and (......), which can be ather reduced into (......), then decarboxylation into (........).

 

59. Specify the transport form of ketone bodies

A. bound to albumin

B. free

C. VLDL

D. HLD

 

 

60. The precursor for the ketone bodiessynthesis is

A. fatty acid

B. glucose

C. acyl-CoA

D. malonyl-CoA

E. succinyl-CoA

 

61. Phospholipids are

A. esters of glycerol and fatty acids

B. esters of glycerol, fatty acids, phosphoric acid and nitrogenous bases

C. esters of cholesterol and fatty acids

 

62. Common metabolite of triacylglycerols and phospholipidssynthesis is

A. dioxyacetone

B. 3- phosphoglycerol aldehyde

C. phosphatidic acid

D. 2 monoacylglycerol

E. 1.2 -diacylglycerol

 

63. Phosphatidylethanolamineis formed by condensation of diacylglycerol and

A. ethanolamine

B. phosphoethanolamine

C. AMP-ethanolamine

 





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