VGG 1. (core) − , . . - , , . (non-core) .
12
(MDA) . , , 8-12 . MDA , , - . MDA 12 . , VGG 8-9 , 3-4 , 14 16 . 2- 3- . ( ) 10 , . VGG - 14-16 , .
( ) . ( T- B-) , . - MDA (, , ).
12 . , () .
, (MLV-vaccines) (core) . 12 () , VGG , 1 3 . (core) (non-core) ( ). , Leptospira, Bordetella, Borrelia (Lyme disease) (CPiV) .
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VGG , ( ), (core + non-core), .
( 12 ) , . ( ), . , .
.
CDV, CPV-2, CAV-1 . ( ) ( -).
, 2 () , / ( ). . - , (non-responder).
.
- :
:
1. − MDA . 14-16 98% .
2. . , , , , , .
3. . , 80- CPV-2 . , non-responder. CPV-2 , . non-responder, CPV-2 - /, (PETS).
DOI
(core) . / (memory effector B cells).
. (core) , (non-core) (Leptospira CPiV). , / (core) .
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, CDV, CPV-2, CAV-1 CAV-2 3 . / , - .
, . , VGG , , .
, , / (viral load) . ( , ) , . - / . ( ) , .
. , , / , ( ).
, ( , , ). ( ), ( ) , , ( ) .
CDV. ( , .) ( ), . .
FPV CPV-2 , . / 24-48 . .
() . , . . VGG .
VGG , ( ).
(CIV) 2009 . - Influenza A subtype H3N8 - , . 6- 2-4 , , . 7 2- . (non-core).
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(leishmaniosis), GP63 ( fucose mannose ligand) Leishmania donovani , , , . / , Leishmania . , 1,3% . , () , . (core) , .
(malignant melanoma) 2007 2010. - ( , ) . , , .
II-IV 90 389 . .
6.