(, ) , " " ( ). : , , .
" " - . ( I,II,V,VII X).
, , . in vitro ( ) . Quick A., 1935 . , . " " - ( V), ( VII), X (), ( II) . , , .
- ( II), . . (, ,, ). . , - , - , .
, , 40%. . - , .
: 1. - V,VII,VIII,XI,XIII; 2. ; 3. ; 4. -.
- ( 2++ , ) . , . ( ) . (: III , ), ( - IV ) .
, . , . VIIa ( "" , ) , X. Xa Va - , , .
. . ( ). , (, ), .
|
|
( , INR) - . : ( , ), () .
- , - II, VII, IX ( -, K). , . , , 2-3 .
, (). . , , . ( , ). ( ).
:
1. " ", .
2. " " () - .
3. " " (, ), %. - 95-105%. ( ) (.. ). , , - . , , - . , .
4. " " (" " - ). 1935 A. Quick. , . . 100%. " ". 70 - 120%. . - . .
5. "".
|
|
, .
, . .
, , , .
.
, , . , , , , .
- .
, .
.
.
11-15 .
: 2-3 .
: 3-5 . 3 4 .
- 80 - 120%.( ).
- . , , II, V, VII, X ( ). , . , (), .
4- - (, ), (warfarin, - Aldocumar, Athrombin - K1, Cofarin, Coumadin, Coumadine, Cumatox, Omefin, Orfarin, Marevan, Panwarfin, Prothromadin, Warfilone, Warnerin).
|
|
1. (%) , . % , . , . . , , , . 50 - 60% 30 - 40% . .
2. ( ), INR (International Normalized Ratio) - , , .
:
INR () = ( / )isi,
ISI (International Sensitivity Index of thromboplastin), ( ) - , .
- , , , . , , . - .
3. ( ) - . , , - .
4. () , %. .