- (, , ) , , , , .
, , , (28).
H5N1 6-8 BALB/c , , , , , 75-100% 6-8 . . A/tk/England/91 (H5N1) , , . ( ) , . , , . , , , A/ck/Scotland/59 (H5N1) A/ck/Queretaro/95 (H5N2), . A/ck/Italy/97 (H5N2) A/tk/England/91 (H5N1) , . , , , . b, (29).
H5N1, , . , , 627 2 . , (30).
: 1, MLD50 0.3 11 PFU, 2, MLD50 103 PFU. 100 PFU 1, 107 PFU/g 3 log , . (>106 PFU/g) 3 6 . , , , . , , .
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, , -. , H5N1 , , , , H5N1 . , , , (31).
, , , H5N1, , H5N1 (32).
, , , , (33, 34, 35, 36, 37, 38, 39, 40).
1997-1999 . H5N1 , .
H5N1 - , . H5N4, , H5N1 H5N1. . - - , , , H5N1 (41).
, A/Duck/Singapore-Q/F119-3/97 (H5N3), H5N1, , H5N1. 70% , 100% , . - . , , (42, 43).
, , A/Ty/Ir/1/83 (H5N8), A/HK/156/97 (H5N1) 12% 1, , H5N1. , , 5 H5N1, (44).
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, , , . , H3N2 LT(R192G), H5N1, 2500 , , LT(R192G). , , H3N2 LT(R192G) , 5 H5N1. LT(R192G) . , , , (45).